Altered stress field of the human lens capsule after cataract surgery.
Altered stress field of the human lens capsule after cataract surgery.
复制标题
白内障手术后人镜囊的应力场改变。
DOI：
10.1016/j.jbiomech.2020.110127
复制
发表时间：
2021-01-22
影响因子：
2.4
通讯作者：
Pedrigi RM
中科院分区：
文献类型：
--
作者：
Berggren CC;Ameku KA;Pedrigi RM
眼睛的透镜囊在调节过程中将光聚焦到视网膜上是重要的，并且在以后的生活中，容纳在白内障手术期间植入的假体透镜。虽然相当多的建模工作的特点是力学的调节，很少有人做，以了解力学的透镜囊后，白内障手术。因此，我们提出了第一个3-D有限元模型的手术后人类透镜囊植入张力环，并分别，人工透镜的特征改变应力场相比，在模型中的本地透镜囊。所有的有限元模型采用Holzapfel超弹性本构模型与各向异性的区域变化。术后透镜囊表现出对应力场的显著扰动，与天然晶状体相比，应力大多大幅降低（除了植入物接触囊的赤道处），其中张力环和人工透镜的柯西应力的最大变化分别为−100%和−145%。然而，与IOL相比，张力环的植入产生了更均匀的应力场。扰动应力场的大小和分布可能是白内障手术后抑制透镜上皮细胞的纤维化反应和相关透镜囊重塑的重要驱动因素。因此，植入物对透镜囊的机械效应可能是设计人工晶状体，特别是具有矫正特征的人工晶状体的基本考虑因素。
The lens capsule of the eye is important in focusing light onto the retina during the process of accommodation and, in later life, housing a prosthetic lens implanted during cataract surgery. Though considerable modeling work has characterized the mechanics of accommodation, little has been done to understand the mechanics of the lens capsule after cataract surgery. As such, we present the first 3-D finite element model of the post-surgical human lens capsule with an implanted tension ring and, separately, an intraocular lens to characterize the altered stress field compared to that in a model of the native lens capsule. All finite element models employed a Holzapfel hyperelastic constitutive model with regional variations in anisotropy. The post-surgical lens capsule demonstrated a dramatic perturbation to the stress field with mostly large reductions in stresses (except at the equator where the implant contacts the capsule) compared to native, wherein maximal changes in Cauchy stress were −100% and −145% for the tension ring and intraocular lens, respectively. However, implantation of the tension ring produced a more uniform stress field compared to the IOL. The magnitudes and distribution of the perturbed stress field may be an important driver of the fibrotic response of inhabiting lens epithelial cells and associated lens capsule remodeling after cataract surgery. Thus, the mechanical effects of an implant on the lens capsule could be an essential consideration in the design of intraocular lenses, particularly those with an accommodative feature.
登录
查看更多内容
影响因子：
13.7
作者：
Hayashi, H;Hayashi, K;Hayashi, F
通讯作者：
Hayashi, F
影响因子：
2.8
作者：
Chang, Anthony;Behndig, Anders;Kugelberg, Maria
通讯作者：
Kugelberg, Maria
影响因子：
3.1
作者：
Halili, Ismail;Mutlu, Fatih Mehmet;Kilic, Selim
通讯作者：
Kilic, Selim
影响因子：
5.5
作者：
FISHER, RF
通讯作者：
FISHER, RF
影响因子：
3.4
作者：
Pedrigi, R. M.;Dziezyc, J.;Humphrey, J. D.
通讯作者：
Humphrey, J. D.