Age-related longitudinal changes in depressive symptoms following breast cancer diagnosis and treatment.
Age-related longitudinal changes in depressive symptoms following breast cancer diagnosis and treatment.
复制标题
DOI：
10.1007/s10549-013-2513-2
复制
发表时间：
2013-05
影响因子：
3.8
通讯作者：
Van Zee, Kimberly J.
中科院分区：
文献类型：
--
作者：
Avis, Nancy E.;Levine, Beverly;Naughton, Michelle J.;Case, L. Douglas;Naftalis, Elizabeth;Van Zee, Kimberly J.
接受乳腺癌治疗的年轻女性在诊断后不久总是比老年女性表现出更大的抑郁。在这项纵向研究中，我们检查这些年龄差异是否在诊断后的前26个月内持续存在，并确定与抑郁症状变化相关的因素。共有653名女性在首次乳腺癌诊断的8个月内完成了基线和三个额外时间点（基线后6，12和18个月）的背景/患者特征，症状和心理社会变量的问卷调查。图表审查提供了癌症和治疗相关数据。主要结局是通过贝克抑郁量表评估的抑郁性精神障碍。在65岁以下的女性中，抑郁症状在诊断后不久最高，并随着时间的推移显着下降。65岁及以上妇女的抑郁症状保持稳定和低水平。在控制了广泛的协变量的多变量分析中，年龄与抑郁症状不再显著相关。与抑郁性精神病水平和下降相关的主要因素是支付基本费用的能力;完成阿霉素化疗;以及疼痛、血管扩张症状、疾病侵入性和被动应对的减少。意义感/和平感和社会支持的增加与抑郁症的减少有关。干预措施，以减少症状和疾病的侵入性，提高意义感和和平，并增加社会支持，可能有助于减少抑郁症，这种干预措施可能是特别相关的年轻妇女。
Younger women being treated for breast cancer consistently show greater depression shortly after diagnosis than older women. In this longitudinal study, we examine whether these age differences persist over the first 26 months following diagnosis and identify factors related to change in depressive symptoms. A total of 653 women within 8 months of a first time breast cancer diagnosis completed questionnaires at baseline and three additional timepoints (6, 12, and 18 months after baseline) on contextual/patient characteristics, symptoms, and psychosocial variables. Chart reviews provided cancer and treatment-related data. The primary outcome was depressive symptomatology assessed by the Beck Depression Inventory. Among women younger than age 65, depressive symptoms were highest soon after diagnosis and significantly decreased over time. Depressive symptoms remained stable and low for women aged 65 and older. Age was no longer significantly related to depressive symptoms in multivariable analyses controlling for a wide range of covariates. The primary factors related to levels of and declines in depressive symptomatology were the ability to pay for basics; completing chemotherapy with doxorubicin; and decreases in pain, vasomotor symptoms, illness intrusiveness, and passive coping. Increased sense of meaning/peace and social support were related to decreased depression. Interventions to reduce symptoms and illness intrusiveness, improve a sense of meaning and peace, and increase social support, may help reduce depression and such interventions may be especially relevant for younger women.
登录
查看更多内容
DOI：
10.1093/jnci/93.21.1615
发表时间：
2001-11-07
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Day, R;Ganz, PA;Costantino, JP
通讯作者：
Costantino, JP
影响因子：
4.2
作者：
Dunn, Laura B.;Cooper, Bruce A.;Miaskowski, Christine
通讯作者：
Miaskowski, Christine
影响因子：
3.6
作者：
McCorry, Noleen K.;Dempster, Martin;Kirk, Stephen J.
通讯作者：
Kirk, Stephen J.
影响因子：
3.6
作者：
Parker, PA;Baile, WF;Cohen, L
通讯作者：
Cohen, L
影响因子：
3.8
作者：
Avis, Nancy E.;Levine, Beverly;Naughton, Michelle J.;Case, Douglas L.;Naftalis, Elizabeth;Van Zee, Kimberly J.
通讯作者：
Van Zee, Kimberly J.