Explaining age-related differences in depression following breast cancer diagnosis and treatment.
Explaining age-related differences in depression following breast cancer diagnosis and treatment.
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DOI：
10.1007/s10549-012-2277-0
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发表时间：
2012-11
影响因子：
3.8
通讯作者：
Van Zee, Kimberly J.
中科院分区：
文献类型：
--
作者：
Avis, Nancy E.;Levine, Beverly;Naughton, Michelle J.;Case, Douglas L.;Naftalis, Elizabeth;Van Zee, Kimberly J.
患有乳腺癌的年轻女性始终表现出比老年女性更大的心理困扰。这项研究调查了一系列可能解释这些年龄差异的因素。共有653名首次诊断为乳腺癌的妇女在8个月内提供了有关患者特征，症状和心理社会变量的数据。图表审查提供了癌症和治疗相关数据。主要结局是通过贝克抑郁量表评估的抑郁性精神障碍。一系列相互建立的模型被用来确定哪些变量可以解释抑郁症的年龄组差异。模型1仅包含年龄组。模型2-5依次增加了患者特征、癌症相关变量、症状和心理社会变量。正如预期的那样，在未调整的分析（模型1）中，年轻女性比老年女性更有可能报告抑郁症（p < 0.0001）。年龄仍然与抑郁症显著相关，直到模型4增加了身体疼痛和血管痉挛症状（p = 0.24; R = 0.27）。在模型5中添加社会心理变量也导致模型中年龄不显著（p = 0.49; R2 = 0.49）。二次分析表明，疾病侵入性（疾病侵入生活的特定领域，如工作，性生活，娱乐等的程度）是唯一的变量，单独考虑与年龄，使年龄组抑郁症的关联不显着。乳腺癌诊断后抑郁风险的年龄差异可以通过癌症及其治疗对女性生活特定领域的影响来解释。
Younger women with breast cancer consistently show greater psychological distress than older women. This study examined a range of factors that might explain these age differences. A total of 653 women within 8 months of a first-time breast cancer diagnosis provided data on patient characteristics, symptoms, and psychosocial variables. Chart reviews provided cancer and treatment-related data. The primary outcome was depressive symptomatology assessed by the Beck Depression Inventory. A succession of models that built hierarchically upon each other was used to determine which variables could account for age group differences in depression. Model 1 contained age group only. Models 2–5 successively added patient characteristics, cancer-related variables, symptoms, and psychosocial variables. As expected, in the unadjusted analysis (Model 1) younger women were significantly more likely to report depressive symptomatology than older women (p < 0.0001). Age remained significantly related to depression until Model 4 which added bodily pain and vasomotor symptoms (p = 0.24; R = 0.27). The addition of psychosocial variables in Model 5 also resulted in a model in which age was nonsignificant (p = 0.49; R2 = 0.49). Secondary analyses showed that illness intrusiveness (the degree that illness intrudes on specific areas of life such as work, sex life, recreation, etc.) was the only variable which, considered individually with age, made the age group-depression association nonsignificant. Age differences in risk of depression following a breast cancer diagnosis can be explained by the impact of cancer and its treatment on specific areas of a woman’s life.
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DOI：
10.1093/jnci/93.21.1615
发表时间：
2001-11-07
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Day, R;Ganz, PA;Costantino, JP
通讯作者：
Costantino, JP
影响因子：
4.2
作者：
Dunn, Laura B.;Cooper, Bruce A.;Miaskowski, Christine
通讯作者：
Miaskowski, Christine
影响因子：
3.4
作者：
Beck, AT;Steer, RA;Ranieri, WF
通讯作者：
Ranieri, WF
影响因子：
45.3
作者：
Bardwell, WA;Natarajan, L;Pierce, JP
通讯作者：
Pierce, JP
影响因子：
--
作者：
DiMatteo, MR;Lepper, HS;Croghan, TW
通讯作者：
Croghan, TW