The Interleukin-20 Cytokines in Intestinal Diseases.
The Interleukin-20 Cytokines in Intestinal Diseases.
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DOI：
10.3389/fimmu.2018.01373
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发表时间：
2018
影响因子：
7.3
通讯作者：
Kaymak T
中科院分区：
文献类型：
--
作者：
Niess JH;Hruz P;Kaymak T
自身免疫性/炎性肠道疾病（例如克罗恩病和溃疡性结肠炎）、传染性胃肠疾病和胃肠癌（例如结肠直肠癌）是世界范围内的重大健康问题。当微生物群定植在胃肠道表面时，细胞间通讯和与环境的直接接触促进了这些疾病。细胞因子介导细胞间通讯，维持宿主与环境的平衡，调节免疫反应。在免疫细胞和上皮细胞之间交换信息的一个细胞因子家族是IL-20细胞因子家族，其包括细胞因子IL-19、IL-20、IL-22、IL-24和IL-26。这些细胞因子共享共同的受体亚基和信号通路。IL-22是该家族中在胃肠道疾病背景下研究最深入的细胞因子，但其他家族成员的重要性越来越受到重视。本文就IL-20细胞因子在胃肠道疾病中的作用进行综述。
Autoimmune/inflammatory intestinal diseases, such as Crohn’s disease and ulcerative colitis, infectious gastrointestinal diseases, and gastrointestinal cancers, such as colorectal cancer, are worldwide a significant health problem. Intercellular communication and direct contact with the environment as the microbiota colonizes the gastrointestinal surface facilitates these diseases. Cytokines mediate the intercellular communication to maintain the equilibrium between host and environment and to regulate immune responses. One cytokine family that exchange information between immune cells and epithelial cells is the IL-20 cytokine family which includes the cytokines IL-19, IL-20, IL-22, IL-24, and IL-26. These cytokines share common receptor subunits and signaling pathways. IL-22 is the most intensively studied cytokine within this family in contexts of gastrointestinal disease, but the importance of other family members is more and more appreciated. In this review, the potential function of IL-20 cytokines concerning gastrointestinal conditions is discussed.
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