Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis.
Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis.
复制标题
DOI：
10.4049/jimmunol.1100123
复制
发表时间：
2011-07-01
期刊：
影响因子：
--
通讯作者：
Bruce AT
中科院分区：
文献类型：
--
作者：
Lin AM;Rubin CJ;Khandpur R;Wang JY;Riblett M;Yalavarthi S;Villanueva EC;Shah P;Kaplan MJ;Bruce AT
IL-17和IL-23是银屑病发病机制的绝对核心，因为靶向细胞因子的药物是这种疾病的高效治疗方法。这些药物的功效归因于阻断产生IL-17的T细胞的功能及其IL-23诱导的扩增。然而，我们证明，肥大细胞和中性粒细胞，而不是T细胞，是人体皮肤中含有IL-17的主要细胞类型。IL-17+肥大细胞和嗜中性粒细胞在银屑病病变中的密度高于IL-17+ T细胞，并且在形成称为细胞外陷阱（分别为MCET和NET）的专门结构的过程中经常释放IL-17。IL-23和IL-1β可诱导人肥大细胞形成MCET和脱颗粒。从先天免疫细胞释放IL-17可能是银屑病发病机制的核心，代表了IL-23-IL-17轴介导宿主防御和自身免疫的基本机制。
IL-17 and IL-23 are absolutely central to psoriasis pathogenesis as drugs targeting either cytokine are highly effective treatments for this disease. The efficacy of these drugs has been attributed to blocking the function of IL-17-producing T cells and their IL-23-induced expansion. However, we demonstrate that mast cells and neutrophils, not T cells, are the predominant cell types that contain IL-17 in human skin. IL-17+ mast cells and neutrophils are found at higher densities than IL-17+ T cells in psoriasis lesions and frequently release IL-17 in the process of forming specialized structures called extracellular traps (MCETs and NETs, respectively). Furthermore, we find that IL-23 and IL-1β can induce MCET formation and degranulation of human mast cells. Release of IL-17 from innate immune cells may be central to the pathogenesis of psoriasis, representing a fundamental mechanism by which the IL-23-IL-17 axis mediates host defense and autoimmunity.
登录
查看更多内容
影响因子：
4.4
作者：
Erbel, Christian;Chen, Lili;Dengler, Thomas J.
通讯作者：
Dengler, Thomas J.
影响因子：
9.8
作者：
Cargill, Michele;Schrodi, Steven J.;Begovich, Ann B.
通讯作者：
Begovich, Ann B.
DOI：
10.1159/000250139
发表时间：
1981-01-01
期刊：
DERMATOLOGICA
影响因子：
--
作者：
CHOWANIEC, O;JABLONSKA, S;RZESA, G
通讯作者：
RZESA, G
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1084/jem.20101048
发表时间：
2010-12-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Guiducci C;Tripodo C;Gong M;Sangaletti S;Colombo MP;Coffman RL;Barrat FJ
通讯作者：
Barrat FJ