In vivo efficiency of praziquantel treatment of single-sex Schistosoma japonicum aged three months old in mice.
In vivo efficiency of praziquantel treatment of single-sex Schistosoma japonicum aged three months old in mice.
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DOI：
10.1016/j.ijpddr.2022.11.002
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发表时间：
2022-12
影响因子：
4
通讯作者：
Lu, Da-Bing
中科院分区：
文献类型：
--
作者：
Wang, Ning;Peng, Han-Qi;Gao, Chang-Zhe;Cheng, Yu-Heng;Sun, Meng-Tao;Qu, Guo-Li;Webster, Joanne P.;Lu, Da-Bing
Schistosomiasis is a major neglected tropical disease mainly caused by Schistosoma haematobium, S. japonicum and S. mansoni, and results in the greatest disease burden. Mass drug administration (MDA) with praziquantel (PZQ), a single drug only available for the disease, has played a vital role in schistosomiasis control. Therefore, any possibility of selection of the parasites for PZQ resistance or low sensitivity may hamper the 2030's target of global disease elimination. We had experimentally demonstrated the long-term survival and reproductive potential of single-sex (of either sex) S. japonicum infections in definitive hosts mice. What has not yet been adequately addressed is whether the long live single-sex schistosomes remain sensitive to PZQ, and what reproduction potential for those schistosomes surviving treatment may have. We therefore performed experimental mice studies to explore the treatment effectiveness of PZQ (at total doses of 200 or 400 mg/kg, corresponding to the sub-standard or standard treatment doses in humans) for single-sex S. japonicum aged three months old. The results showed that no treatment efficiency was observed on female schistosomes, whereas on male schistosomes only at PZQ 400 mg/kg a significant higher efficiency in reducing worm burdens was observed. Moreover, either schistosome males or females surviving PZQ treatment remained their reproduction potential as normal. The results indicate that long (i.e., three months) live single-sex S. japonicum can easily survive the current treatment strategy, and moreover, any schistosomes, if with PZQ resistance or low sensitivity, could be easily transmitted in nature. Therefore, in order to realize the target for the national and the global schistosomiasis elimination, there is undoubtedly a great need for refining PZQ administration and dosage, looking for alternative therapies, and/or developing vaccines against schistosome. PZQ efficiency of three-month-old single-sex S. japonicum was tested on mice. No treatment efficiency was observed on females at total doses PZQ 200 or 400 mg/kg. Significance in reducing worm burdens was observed on males only at PZQ 400 mg/kg. Survived schistosome females or males remained their normal reproduction potential. S. japonicum with PZQ resistance or low sensitivity could be easily transmitted.
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影响因子：
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作者：
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通讯作者：
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DOI：
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DOI：
10.1016/j.ijpddr.2020.10.003
发表时间：
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期刊：
International journal for parasitology. Drugs and drug resistance
影响因子：
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