Deep imaging of absorption and scattering features by multispectral multiple scattering low coherence interferometry.
Deep imaging of absorption and scattering features by multispectral multiple scattering low coherence interferometry.
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通过多光谱多重散射低相干干涉测量对吸收和散射特征进行深度成像。
DOI：
10.1364/boe.7.003916
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发表时间：
2016
影响因子：
3.4
通讯作者：
Adam Wax
中科院分区：
文献类型：
--
作者：
Yang Zhao;Jason R. Maher;Mohamed M Ibrahim;Jennifer S. Chien;H. Levinson;Adam Wax
我们开发了用于吸收和散射对比深度成像的频域多光谱多散射低相干干涉法（ms2/LCI）。使用与人体真皮组织的全散射相位函数相匹配的组织模拟模型，我们证明ms2/LCI在成像深度为1mm时可以提供比传统OCT提高15.4 dB的信噪比（SNR）。ms2/LCI提供的增强的信噪比和穿透深度可用于各种临床应用，包括评估烧伤，目前的临床严重程度分类仅提供有限的准确性。通过对模拟部分厚度烧伤的组织模体成像，证明了该方法的实用性，揭示了样本表面深处健康和受伤组织区域之间良好的光谱对比。最后，使用商用OCT仪器和我们定制的ms2/LCI系统对健康大鼠皮肤进行体内成像。结果表明，ms2/LCI能够获得远超常规OCT穿透深度的光谱信息。
We have developed frequency domain multispectral multiple scattering low coherence interferometry (ms2/LCI) for deep imaging of absorption and scattering contrast. Using tissue-mimicking phantoms that match the full scattering phase function of human dermal tissue, we demonstrate that ms2/LCI can provide a signal/noise ratio (SNR) improvement of 15.4 dB over conventional OCT at an imaging depth of 1 mm. The enhanced SNR and penetration depth provided by ms2/LCI could be leveraged for a variety of clinical applications including the assessment of burn injuries where current clinical classification of severity only provides limited accuracy. The utility of the approach was demonstrated by imaging a tissue phantom simulating a partial-thickness burn revealing good spectroscopic contrast between healthy and injured tissue regions deep below the sample surface. Finally, healthy rat skin was imaged in vivo with both a commercial OCT instrument and our custom ms2/LCI system. The results demonstrate that ms2/LCI is capable of obtaining spectroscopic information far beyond the penetration depth provided by conventional OCT.
影响因子：
38.3
作者：
通讯作者：
--
影响因子：
3.4
作者：
Kanick, Stephen Chad;McClatchy, David M., III;Pogue, Brian W.
通讯作者：
Pogue, Brian W.