Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation
Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation
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应激适应过程中血清素消耗对海马 GR/MR 和 BDNF 表达的影响
DOI：
10.1016/j.bbr.2008.06.009
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发表时间：
2008-12
影响因子：
2.7
通讯作者：
Zhang, Xianghui
中科院分区：
文献类型：
--
作者：
Li, Changqi;Li, Zexuan;Li, Weihui;Tang, Shaojun;Zhou, Jiansong;Li, Lingjiang;Cao, Xia;Zhang, Xianghui
反复应激诱导的海马区5-羟色胺(5-羟色胺，5-HT)释放增加，被认为是减轻应激源对情绪和行为的不利影响的神经适应的关键。这一过程的失败可能是导致应激相关障碍的主要神经病理机制之一。用对氯苯丙胺(p-PCA)在重复束缚应激(6h/d，10d)前耗竭5-羟色胺(5-羟色胺)，观察5-羟色胺耗竭对应激诱导的动物行为改变、海马区皮质类固醇受体免疫反应性和脑源性神经营养因子(BDNF)基因表达的影响。行为学测试表明，5-羟色胺缺乏的应激大鼠表现出明显的焦虑，奖赏敏感度降低，习得性无助增强。此外，他们还在莫里斯水迷宫测试中出现了学习障碍。这些结果表明，海马区5-羟色胺的缺乏损害了对慢性应激的适应。此外，反复应激引起糖皮质激素受体表达的增加和BDNF基因表达的下调。本研究提示，成年大鼠海马区5-羟色胺缺乏可能通过抑制海马区GR和BDNF的表达而损害应激适应。
Increased serotonin (5-hydroxytryptamine, 5-HT) release in the hippocampus induced by repeated stress is thought to be critical for the neuroadaptation that alleviates the adverse effects of stressors on emotion and behavior. A failure in this process may be one of the primary neuropathological mechanisms underlying the development of stress-related disorders. The para-chloroamphetamine (p-PCA) was used to deplete 5-HT in the rat prior to repeated restraint stress (6h/day for 10 days), and determined the consequences of 5-HT depletion on stress-induced alterations of animal behaviors, hippocampal corticosteroid receptor immunoreactivity and the brain-derived neurotrophic factor (BDNF) mRNA expression. Behavioral tests indicate that the stressed rats with 5-HT depletion showed pronounced anxiety, reduced reward sensitivity and enhanced learned-helplessness. In addition, they also developed learning impairments in Morris water maze tests. These results suggest that hippocampal 5-HT depletion compromised adaptation to chronic stress. Furthermore, repeated stress caused a lesser degree of glucocorticoid receptor increase and down-regulation of BDNF mRNA. The study suggest that 5-HT deficiency in the adult hippocampus may impair stress adaptation by suppressing hippocampal GR and BDNF expression.
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影响因子：
2.9
作者：
T. Ueyama;Y. Kawai;K. Nemoto;M. Sekimoto;S. Toné;E. Senba
通讯作者：
T. Ueyama;Y. Kawai;K. Nemoto;M. Sekimoto;S. Toné;E. Senba
影响因子：
2.9
作者：
Yoshifumi Watanabe;E. Gould;B. McEwen
通讯作者：
Yoshifumi Watanabe;E. Gould;B. McEwen
影响因子：
19.6
作者：
de Kloet, ER;van Acker, SABE;de Jong, W
通讯作者：
de Jong, W
DOI：
10.1073/pnas.0337481100
发表时间：
2003-02-04
影响因子：
11.1
作者：
MacQueen, GM;Campbell, S;Young, LT
通讯作者：
Young, LT
影响因子：
2.9
作者：
McEwen, BS
通讯作者：
McEwen, BS