Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney.
Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney.
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DOI：
10.3389/fped.2022.853722
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发表时间：
2022
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
当活性氧/活性氮和抗氧化系统之间存在不平衡时，就会发生氧化应激。这些复杂过程之间的相互作用对于正常妊娠和胎儿发育至关重要;然而，当氧化应激占主导地位时，妊娠相关并发症和不利的胎儿编程，如早产。了解氧化应激如何对母胎二分体的结局产生负面影响，可以探索抗氧化疗法来预防和/或缓解疾病进展。在发育中的肾脏中，氧化应激的负面影响也已被注意到，因为它主要在动物模型中与高血压和肾损伤的发展有关。与早产儿和其他脆弱新生儿群体的神经发育和呼吸系统疾病相比，针对发育中肾脏氧化应激影响的临床研究尚不成熟。努力研究氧化应激通路沿着连续的围产期使用团队科学的方法可以帮助理解的多器官功能障碍，母胎二分体维持和指导调查的抗氧化剂治疗，以改善全球的毒性。这篇教育评论将提供一个全面和多学科的观点，对围产期氧化应激在孕产妇和胎儿/新生儿并发症的发展中的影响，以及对加速衰老和心血管和肾脏疾病的发展规划的影响。
Oxidative stress occurs when there is an imbalance between reactive oxygen species/reactive nitrogen species and antioxidant systems. The interplay between these complex processes is crucial for normal pregnancy and fetal development; however, when oxidative stress predominates, pregnancy related complications and adverse fetal programming such as preterm birth ensues. Understanding how oxidative stress negatively impacts outcomes for the maternal-fetal dyad has allowed for the exploration of antioxidant therapies to prevent and/or mitigate disease progression. In the developing kidney, the negative impact of oxidative stress has also been noted as it relates to the development of hypertension and kidney injury mostly in animal models. Clinical research addressing the implications of oxidative stress in the developing kidney is less developed than that of the neurodevelopmental and respiratory conditions of preterm infants and other vulnerable neonatal groups. Efforts to study the oxidative stress pathway along the continuum of the perinatal period using a team science approach can help to understand the multi-organ dysfunction that the maternal-fetal dyad sustains and guide the investigation of antioxidant therapies to ameliorate the global toxicity. This educational review will provide a comprehensive and multidisciplinary perspective on the impact of oxidative stress during the perinatal period in the development of maternal and fetal/neonatal complications, and implications on developmental programming of accelerated aging and cardiovascular and renal disease for a lifetime.
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DOI：
10.1007/s00467-015-3087-5
发表时间：
2015-09
期刊：
Pediatric nephrology (Berlin, Germany)
影响因子：
--
作者：
Askenazi D;Patil NR;Ambalavanan N;Balena-Borneman J;Lozano DJ;Ramani M;Collins M;Griffin RL
通讯作者：
Griffin RL
影响因子：
5.5
作者：
Cao W;Hou FF;Nie J
通讯作者：
Nie J
影响因子：
2.1
作者：
Biri, Aydan;Bozkurt, Nuray;Durak, Ilker
通讯作者：
Durak, Ilker
影响因子：
8.3
作者：
Bertagnolli, Mariane;Huyard, Fanny;Nuyt, Anne Monique
通讯作者：
Nuyt, Anne Monique
影响因子：
3
作者：
Abitbol, Carolyn L.;Chandar, Jayanthi;Zilleruelo, Gaston
通讯作者：
Zilleruelo, Gaston