Altered resting state functional connectivity in young survivors of acute lymphoblastic leukemia.
Altered resting state functional connectivity in young survivors of acute lymphoblastic leukemia.
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DOI：
10.1002/pbc.25022
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发表时间：
2014-07
影响因子：
3.2
通讯作者：
Lacayo, Norman
中科院分区：
文献类型：
--
作者：
Kesler, Shelli R.;Gugel, Meike;Pritchard-Berman, Mika;Lee, Clement;Kutner, Emily;Hosseini, S. M. Hadi;Dahl, Gary;Lacayo, Norman
关键词：
Chemotherapy treatment for pediatric acute lymphoblastic leukemia (ALL) has been associated with long-term cognitive impairments in some patients. However, the neurobiologic mechanisms underlying these impairments, particularly in young survivors, are not well understood. This study aimed to examine intrinsic functional brain connectivity in pediatric ALL and its relationship with cognitive status. We obtained resting state functional magnetic resonance imaging (rsfMRI) and cognitive testing data from 15 ALL survivors age 8–15 years and 14 matched healthy children. The ALL group had a history of intrathecal chemotherapy treatment but were off-therapy for at least 6 months at the time of enrollment. We used seed-based analyses to compare intrinsic functional brain network connectivity between the groups. We also explored correlations between connectivity and cognitive performance, demographic, medical, and treatment variables. We demonstrated significantly reduced connectivity between bilateral hippocampus, left inferior occipital, left lingual gyrus, bilateral calcarine sulcus, and right amygdala in the ALL group compared to controls. The ALL group also showed regions of functional hyperconnectivity including right lingual gyrus, precuneus, bilateral superior occipital lobe, and right inferior occipital lobe. Functional hypoconnectivity was associated with reduced cognitive function as well as younger age at diagnosis in the ALL group. This is the first study to demonstrate that intrinsic functional brain connectivity is disrupted in pediatric ALL following chemotherapy treatment. These results help explain cognitive dysfunction even when objective test performance is seemingly normal. Children diagnosed at a younger age may show increased vulnerability to altered functional brain connectivity.
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影响因子：
5.7
作者：
Hosseini, S. M. Hadi;Kesler, Shelli R.
通讯作者：
Kesler, Shelli R.
影响因子：
10.3
作者：
Conklin, H. M.;Krull, K. R.;Pui, C. H.
通讯作者：
Pui, C. H.
DOI：
10.1073/pnas.1018985108
发表时间：
2011-05-03
影响因子：
11.1
作者：
Bassett, Danielle S.;Wymbs, Nicholas F.;Grafton, Scott T.
通讯作者：
Grafton, Scott T.
影响因子：
3.7
作者：
Hosseini SM;Hoeft F;Kesler SR
通讯作者：
Kesler SR
影响因子：
3.6
作者：
Kahalley, Lisa S.;Conklin, Heather M.;Hinds, Pamela S.
通讯作者：
Hinds, Pamela S.