MtsslWizard: In Silico Spin-Labeling and Generation of Distance Distributions in PyMOL.

MtsslWizard: In Silico Spin-Labeling and Generation of Distance Distributions in PyMOL.
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DOI:
10.1007/s00723-012-0314-0
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发表时间:
2012-04
影响因子:
1
通讯作者:
Schiemann, Olav
Schiemann, Olav
中科院分区:
物理与天体物理4区
文献类型:
--
作者:
Hagelueken, Gregor;Ward, Richard;Naismith, James H.;Schiemann, Olav

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MtsslWizard是一个计算机程序,它作为PyMOL分子图形系统的插件运行。MtsslWizard通过简单的图形界面快速估计蛋白质上自旋标签之间的距离,用户可配置选项。在默认模式下,程序搜索可能的MTSSL构象的集合,这些构象不会与蛋白质的静态模型冲突。一旦确定了构象,就可以计算、显示两个或多个组合之间的距离分布,并可以导出到其他软件。在许多具有挑战性的测试用例中评估程序的使用,并评估其优点和缺点。该程序的优点是它的准确性和简单性。本文的在线版本(doi:10.1007/s00723-012-0314-0)包含补充资料,仅供授权用户使用。
MtsslWizard is a computer program, which operates as a plugin for the PyMOL molecular graphics system. MtsslWizard estimates distances between spin labels on proteins quickly with user-configurable options through a simple graphical interface. In default mode, the program searches for ensembles of possible MTSSL conformations that do not clash with a static model of the protein. Once conformations are assigned, distance distributions between two or more ensembles are calculated, displayed, and can be exported to other software. The program’s use is evaluated in a number of challenging test cases and its strengths and weaknesses evaluated. The benefits of the program are its accuracy and simplicity. The online version of this article (doi:10.1007/s00723-012-0314-0) contains supplementary material, which is available to authorized users.
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