An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors.
An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors.
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DOI：
10.1242/dev.015081
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发表时间：
2008-01
期刊：
影响因子：
4.6
通讯作者：
Martin, Gail R.
中科院分区：
文献类型：
--
作者：
Klein, Ophir D.;Lyons, David B.;Balooch, Guive;Marshall, Grayson W.;Basson, M. Albert;Peterka, Miroslav;Boran, Tomas;Peterkova, Renata;Martin, Gail R.
啮齿类动物的门牙在整个成年期都在生长，但由于门牙一侧没有釉质，因此经常磨损会防止门牙变得过长。在这里，我们报告的Sprouty基因，它编码受体酪氨酸激酶信号的拮抗剂的功能丧失，导致双边釉质沉积，从而阻碍门牙磨损，并导致在不受限制的牙齿伸长。我们证明，Sprouty基因的功能，以确保釉质生产成釉细胞只产生在一侧的牙齿，通过抑制异位成釉细胞的形成自我更新的干细胞，他们这样做是通过防止建立一个上皮间质FGF信号环。有趣的是，虽然Spry4的失活单独启动胚胎中的异位成釉细胞形成，但另一个Sprouty基因的剂量也必须减少，以在出生后维持它。这些数据表明，从特定干细胞群体分化后代的产生在胚胎和成体中可以受到不同的调节。
Rodent incisors grow throughout adult life, but are prevented from becoming excessively long by constant abrasion, which is facilitated by the absence of enamel on one side of the incisor. Here we report that loss-of-function of Sprouty genes, which encode antagonists of receptor tyrosine kinase signaling, leads to bilateral enamel deposition, thus impeding incisor abrasion and resulting in unchecked tooth elongation. We demonstrate that Sprouty genes function to ensure that enamel-producing ameloblasts are generated on only one side of the tooth by inhibiting the formation of ectopic ameloblasts from self-renewing stem cells, and that they do so by preventing the establishment of an epithelial-mesenchymal FGF signaling loop. Interestingly, whilst inactivation of Spry4 alone initiates ectopic ameloblast formation in the embryo, the dosage of another Sprouty gene must also be reduced to sustain it after birth. These data reveal that the generation of differentiated progeny from a particular stem cell population can be differently regulated in the embryo and adult.
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影响因子：
64.8
作者：
MATZUK, MM;LU, NF;BRADLEY, A
通讯作者：
BRADLEY, A
影响因子：
4.6
作者：
Yokohama-Tamaki, T;Ohshima, H;Harada, H
通讯作者：
Harada, H
影响因子：
7.8
作者：
Harada, H;Kettunen, P;Jung, H S;Mustonen, T;Wang, Y A;Thesleff, I
通讯作者：
Thesleff, I
影响因子：
11.8
作者：
Klein, Ophir D.;Minowada, George;Martin, Gail R.
通讯作者：
Martin, Gail R.
影响因子：
6.2
作者：
Kinney, JH;Haupt, DL;Lane, NE
通讯作者：
Lane, NE