Similar connotation in chronic hepatitis B and nonalcoholic Fatty liver patients with dampness-heat syndrome.
Similar connotation in chronic hepatitis B and nonalcoholic Fatty liver patients with dampness-heat syndrome.
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DOI：
10.1155/2013/793820
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Cao Z
中科院分区：
文献类型：
--
作者：
Dai J;Sun S;Cao J;Zhao Y;Cao H;Zheng N;Fang J;Wang Y;Zhang W;Zhang Y;Hu Y;Cao Z
不同疾病同证的现象出现在世界各地人们的视野中，这引发了“异病同治”可能性的思考。事实上，基于中医郑氏分类的治疗可以为前者的发现带来启示。以慢性乙型肝炎和非酒精性脂肪肝的湿热证为突破口。我们通过代谢组学探讨了慢性乙型肝炎和非酒精性脂肪肝中存在相似内涵的分子机制，以给出对湿热证的现代认识。尿液和血清代谢谱显示，湿热证与非湿热证之间存在明显差异，但在慢性乙型肝炎和非酒精性脂肪肝湿热证患者中存在共性。进而发现体液代谢紊乱、消化能力下降、肠道菌群失衡等问题成为新的治疗指导，有望为中医个体化医疗提供依据。
The phenomenon that the same syndrome turns up in different diseases appears in the sight of people around the world, which raises the thought for possibility of “Same Treatment for Different Diseases.” Actually, treatment based on ZHENG classification in Traditional Chinese Medicine could bring revelation for the former finding. The dampness-heat syndrome in chronic hepatitis B and nonalcoholic fatty liver is regarded as the breakthrough point. We discussed the molecular mechanism of similar connotation that exists in chronic hepatitis B and nonalcoholic fatty liver by metabonomics to give the modern understanding of dampness-heat syndrome. Both urine and serum metabolic profiling revealed that obvious differences existed between dampness-heat syndrome and non-dampness-heat syndrome but the commonality was proved to appear in chronic hepatitis B and nonalcoholic fatty liver patients with dampness-heat syndrome. Furthermore, disorder of body fluid metabolism, decline in digestive capacity, and imbalance of intestinal flora were found to be the new guiding for treatment, with the hope to provide the basis for Chinese personalized medicine.
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