Locus coeruleus activity while awake is associated with REM sleep quality in older individuals.
Locus coeruleus activity while awake is associated with REM sleep quality in older individuals.
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DOI：
10.1172/jci.insight.172008
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发表时间：
2023-10-23
期刊：
影响因子：
8
通讯作者：
Vandewalle, Gilles
中科院分区：
文献类型：
--
作者：
Koshmanova, Ekaterina;Berger, Alexandre;Beckers, Elise;Campbell, Islay;Mortazavi, Nasrin;Sharifpour, Roya;Paparella, Ilenia;Balda, Fermin;Berthomier, Christian;Degueldre, Christian;Salmon, Eric;Lamalle, Laurent;Bastin, Christine;Van Egroo, Maxime;Phillips, Christophe;Maquet, Pierre;Collette, Fabienne;Muto, Vincenzo;Chylinski, Daphne;Jacobs, Heidi I. L.;Talwar, Puneet;Sherif, Siya;Vandewalle, Gilles
蓝斑 (LC) 是大脑中去甲肾上腺素的主要来源，调节觉醒和睡眠。动物研究表明，它在睡眠和清醒之间以及慢波睡眠和快速眼动睡眠（REMS）之间的过渡中发挥着重要作用。然而，目前尚不清楚 LC 的活动是否可以预测人类的睡眠变异性。我们使用 7 特斯拉功能 MRI、睡眠脑电图 (EEG) 和睡眠问卷来测试 33 名健康年轻人（约 22 岁；28 名女性，5 名男性）和 19 名老年人（约 61 岁；14 名女性，5 名男性）清醒时的 LC 活动是否与睡眠质量相关。我们发现，在老年参与者中，但在年轻参与者中则不然，在听觉注意力任务期间检测到的较高的 LC 活动与较差的主观睡眠质量以及 REMS 期间脑电图 θ 带的较低功率相关。即使考虑了与年龄相关的 LC 完整性变化，结果仍然稳健。这些发现表明，LC 活性与睡眠质量的感知和 REMS 的基本振荡模式相关，我们发现 LC 可能是治疗睡眠和年龄相关疾病的重要靶点。这项工作得到了国家科学研究基金会 (FRS-FNRS、T.0242.19 和 J. 0222.20)、Action de Recherche Concertée – Fédération Wallonie-Bruxelles (ARC SLEEPDEM 17/27-09)、阿尔茨海默病研究基金会 (SAO-FRA 2019/0025)、 ULiège 和欧洲区域发展基金（Radiomed & Biomed-Hub）。
The locus coeruleus (LC) is the primary source of norepinephrine in the brain and regulates arousal and sleep. Animal research shows that it plays important roles in the transition between sleep and wakefulness, and between slow wave sleep and rapid eye movement sleep (REMS). It is unclear, however, whether the activity of the LC predicts sleep variability in humans. We used 7-Tesla functional MRI, sleep electroencephalography (EEG), and a sleep questionnaire to test whether the LC activity during wakefulness was associated with sleep quality in 33 healthy younger (~22 years old; 28 women, 5 men) and 19 older (~61 years old; 14 women, 5 men) individuals. We found that, in older but not in younger participants, higher LC activity, as probed during an auditory attentional task, was associated with worse subjective sleep quality and with lower power over the EEG theta band during REMS. The results remained robust even when accounting for the age-related changes in the integrity of the LC. These findings suggest that LC activity correlates with the perception of the sleep quality and an essential oscillatory mode of REMS, and we found that the LC may be an important target in the treatment of sleep- and age-related diseases. This work was supported by Fonds National de la Recherche Scientifique (FRS-FNRS, T.0242.19 & J. 0222.20), Action de Recherche Concertée – Fédération Wallonie-Bruxelles (ARC SLEEPDEM 17/27-09), Fondation Recherche Alzheimer (SAO-FRA 2019/0025), ULiège, and European Regional Development Fund (Radiomed & Biomed-Hub).
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影响因子：
12.7
作者：
Braak, Heiko;Del Tredici, Kelly
通讯作者：
Del Tredici, Kelly
DOI：
10.1016/j.cortex.2017.09.025
发表时间：
2017-12
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Elman JA;Panizzon MS;Hagler DJ Jr;Eyler LT;Granholm EL;Fennema-Notestine C;Lyons MJ;McEvoy LK;Franz CE;Dale AM;Kremen WS
通讯作者：
Kremen WS
影响因子：
4.3
作者：
Gong L;Shi M;Wang J;Xu R;Yu S;Liu D;Ding X;Zhang B;Zhang X;Xi C
通讯作者：
Xi C
影响因子：
3
作者：
Duff, Eugene P.;Cunnington, Ross;Egan, Gary F.
通讯作者：
Egan, Gary F.
影响因子：
3.4
作者：
Carrier, Julie;Viens, Isabelle;Filipini, Daniel
通讯作者：
Filipini, Daniel