The Abnormal Functional Connectivity in the Locus Coeruleus-Norepinephrine System Associated With Anxiety Symptom in Chronic Insomnia Disorder.
The Abnormal Functional Connectivity in the Locus Coeruleus-Norepinephrine System Associated With Anxiety Symptom in Chronic Insomnia Disorder.
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慢性失眠症患者蓝斑-去甲肾上腺素系统功能连接异常与焦虑症状的关系
DOI：
10.3389/fnins.2021.678465
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发表时间：
2021
影响因子：
4.3
通讯作者：
Xi C
中科院分区：
文献类型：
--
作者：
Gong L;Shi M;Wang J;Xu R;Yu S;Liu D;Ding X;Zhang B;Zhang X;Xi C
焦虑和抑郁等精神症状是慢性失眠障碍(CID)患者常见的共病。蓝斑去甲肾上腺素(LC-NE)系统被认为是调节情绪和睡眠/觉醒周期的关键。LC-NE系统也是应激性焦虑的重要调节因子。然而，LC-NE系统是否参与了失眠和这些共病的潜在机制尚不清楚。本研究旨在探讨失眠症患者LC-NE系统的变化及其与抑郁、焦虑症状的关系。对70例CID患者和63例匹配的良好睡眠对照(GSC)受试者进行静息状态功能MRI扫描。采用基于种子的功能连接性(FC)分析方法构建LC-NE功能网络。探讨CID患者LC-NE Fc网络的变化及其临床意义。与GSC组相比，CID组左侧额下回LC-NE Fc降低，而左缘上回和左枕中回Lc-NE Fc升高。右侧LC-NE Fc网络左侧背侧前扣带回(DACC)Fc降低。有趣的是，LC-NE Fc增加位于感觉皮层，而Lc-NE Fc减少位于额叶对照皮质。此外，左侧LC和左侧MOG之间的FC与病程有关，而右侧LC和左侧DACC之间的FC异常与CID患者的焦虑评分有关。本研究发现CID患者存在LC-NE功能网络异常，DACC中LC-NE功能异常与CID患者的焦虑症状有关。本研究极大地加深了我们对CID神经病理基础的认识，并为同时存在焦虑的CID患者提供了潜在的治疗靶点。
Mental syndromes such as anxiety and depression are common comorbidities in patients with chronic insomnia disorder (CID). The locus coeruleus noradrenergic (LC-NE) system is considered to be crucial for modulation of emotion and sleep/wake cycle. LC-NE system is also a critical mediator of the stress-induced anxiety. However, whether the LC-NE system contributes to the underlying mechanism linking insomnia and these comorbidities remain unclear. This study aimed to investigate the LC-NE system alterations in patients with insomnia and its relationship with depression and anxiety symptoms. Seventy patients with CID and 63 matched good sleep control (GSC) subjects were recruited and underwent resting-state functional MRI scan. LC-NE functional network was constructed by using seed-based functional connectivity (FC) analysis. The alterations in LC-NE FC network in patients with CID and their clinical significance was explored. Compared with GSC group, the CID group showed decreased left LC-NE FC in the left inferior frontal gyrus, while they had increased LC-NE FC in the left supramarginal gyrus and the left middle occipital gyrus (MOG). For the right LC-NE FC network, decreased FC was found in left dorsal anterior cingulate cortex (dACC). Interesting, the increased LC-NE FC was located in sensory cortex, while decreased LC-NE FC was located in frontal control cortex. In addition, the FC between the left LC and left MOG was associated with the duration of the disease, while abnormal FC between right LC and left dACC was associated with the anxiety scores in patients with CID. The present study found abnormal LC-NE functional network in patients with CID, and the altered LC-NE function in dACC was associated with anxiety symptoms in CID. The present study substantially extended our understanding of the neuropathological basis of CID and provided the potential treatment target for CID patients who also had anxiety.
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影响因子：
2.6
作者：
Chen, Michael C.;Chang, Catie;Glover, Gary H.;Gotlib, Ian H.
通讯作者：
Gotlib, Ian H.
影响因子：
6.6
作者：
Gong, Liang;Xu, Ronghua;Xi, Chunhua
通讯作者：
Xi, Chunhua
影响因子：
4.7
作者：
Backhaus, J;Junghanns, K;Hohagen, F
通讯作者：
Hohagen, F
影响因子：
4.1
作者：
Bragantini, Daniela;Sivertsen, Borge;Guzey, Ismail Cuneyt
通讯作者：
Guzey, Ismail Cuneyt
影响因子：
11.3
作者：
BUYSSE, DJ;REYNOLDS, CF;KUPFER, DJ
通讯作者：
KUPFER, DJ