BMP signaling protects telencephalic fate by repressing eye identity and its Cxcr4-dependent morphogenesis.
BMP signaling protects telencephalic fate by repressing eye identity and its Cxcr4-dependent morphogenesis.
复制标题
DOI：
10.1016/j.devcel.2012.09.006
复制
发表时间：
2012-10-16
影响因子：
11.8
通讯作者：
Houart C
中科院分区：
文献类型：
--
作者：
Bielen H;Houart C
Wnt信号转导的耗尽是前脑前部诱导的主要要求。然而，分子事件驱动的差异区域化，这方面的眼睛领域和端脑的命运仍然是未知的。在这里，我们表明，BMP途径是活跃的前神经外胚层在囊胚晚期早期原肠胚阶段在斑马鱼。Bmp2b突变体和嵌合体功能丧失实验表明，BMP通过抑制其关键转录因子Rx3作为眼场命运的阻遏物，从而保护未来的端脑免于获得眼睛身份。这种BMP驱动的机制在Wnt拮抗剂从前神经边界参与之前启动端脑的建立。此外，我们证明，Rx3和BMP分别需要维持和限制趋化因子受体cxcr4a，这反过来又有助于在早期神经形成的眼区和端脑细胞的形态发生分离。
Depletion of Wnt signaling is a major requirement for the induction of the anterior prosencephalon. However, the molecular events driving the differential regionalization of this area into eye-field and telencephalon fates are still unknown. Here we show that the BMP pathway is active in the anterior neural ectoderm during late blastula to early gastrula stage in zebrafish. Bmp2b mutants and mosaic loss-of-function experiments reveal that BMP acts as a repressor of eye-field fate through inhibition of its key transcription factor Rx3, thereby protecting the future telencephalon from acquiring eye identity. This BMP-driven mechanism initiates the establishment of the telencephalon prior to the involvement of Wnt antagonists from the anterior neural border. Furthermore, we demonstrate that Rx3 and BMP are respectively required to maintain and restrict the chemokine receptor cxcr4a, which in turn contributes to the morphogenetic separation of eye-field and telencephalic cells during early neurulation.
登录
查看更多内容
影响因子：
2.7
作者：
Kennedy, BN;Stearns, GW;Brockerhoff, SE
通讯作者：
Brockerhoff, SE
影响因子：
2.7
作者：
Hartley, KO;Hardcastle, Z;Papalopulu, N
通讯作者：
Papalopulu, N
影响因子：
5.3
作者：
Cheng, Xun;Hsu, Ching-mei;Monuki, Edwin S.
通讯作者：
Monuki, Edwin S.
影响因子：
64.8
作者：
Mathers, PH;Grinberg, A;Jamrich, M
通讯作者：
Jamrich, M
影响因子：
16.2
作者：
Houart, C;Caneparo, L;Wilson, SW
通讯作者：
Wilson, SW