Prostaglandins in Cancer Research

Prostaglandins in Cancer Research
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前列腺素在癌症研究中的应用

DOI:
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发表时间:
1987
期刊:
Proceedings in Life Sciences
影响因子:
--
通讯作者:
Consiglio naxionale delle ricerche
Consiglio naxionale delle ricerche
中科院分区:
--
文献类型:
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作者:
E. Garaci;R. Paoletti;M. Santoro;Consiglio naxionale delle ricerche

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花生四烯酸代谢产物作为微环境激素和细胞内信号介质在许多生物系统中发挥调节作用。这些化合物最令人兴奋的研究领域之一是研究野牡丹素与肿瘤细胞生长和功能之间的关系。在过去的几年里,关于三尖杉酯碱(及其相关化合物)和癌症的数据有了惊人的发展。本卷基于1986年6月在意大利罗马举行的意大利国家研究理事会和罗马第二大学组织的1986年国际前列腺素和癌症会议上提交的论文。本次会议汇集了前列腺素化学,生物化学,药理学,生理学,细胞和分子生物学领域的肿瘤学家和专家,概述了类花生酸在癌症中作用的实际知识状况,并专注于需要回答的关键问题。从这本书中出来的图片描述了一个非常复杂的花生四烯酸代谢物之间相互作用的网络,以及复杂现象“癌症”的不同方面。“类花生酸参与致癌的启动和促进,它们与肿瘤促进剂和生长因子的关系已经建立。在肿瘤生长过程中,不同的野牡丹素在调节细胞增殖和分化以及转移形成中可以具有不同的作用;同时,对于这些化合物中的一些可能用作肿瘤抑制剂的证据正在积累。"
Arachidonic acid metabolites are known to playa regulatory role in a number of biological systems, in which they function as microenviron mental hormones and intracellular signal mediators. One of the most exciting areas of research of these compounds is the one that studies the relationship between prostaglandins and tumor cell growth and function. In the last few years there has been an extraordinary evolution of data on prostaglandins (and related compounds) and cancer. This vol ume is based on papers presented at the 1986 International Confer ence on Prostaglandins and Cancer organized by the Italian National Research Council and the II University of Rome, and held in Rome, Italy, in June, 1986. This Conference brought together oncologists and specialists in the areas of prostaglandin chemistry, biochemistry, pharmacology, physiology, cellular and molecular biology to overview the actual state of knowledge on the role of eicosanoids in cancer and to focus on the key questions that need to be answered. The picture that comes out of this book describes a very complicated network of interactions between arachidonic acid metabolites and different as pects of the complex phenomenon "cancer." Eicosanoids participate in carcinogenesis initiation and promotion, and their relationship with tumor promoters and growth factors is well established. During cancer growth, different prostaglandins can have different roles in the regulation of cell proliferation and differentiation and in metastasis formation; meanwhile evidence is accumulating for a pos sible use of some of these compounds as antineoplastic agents."
巨噬细胞释放白三烯 C。
DOI: --
发表时间: 1983
期刊: Federation proceedings
影响因子: --
作者:
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A系列前列腺素的抗病毒作用:抑制培养细胞中痘苗病毒的复制。
DOI: 10.1099/0022-1317-63-2-435
发表时间: 1982
期刊: The Journal of general virology
影响因子: --
作者:
Santoro,MG;Jaffe,BM;Garaci,E;Esteban,M
通讯作者: Esteban,M
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发表时间: 1986-01
影响因子: 4.4
作者:
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DOI: --
发表时间: 1983
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Dinarello,CA;Marnoy,SO;Rosenwasser,LJ
通讯作者: Rosenwasser,LJ
DOI: --
发表时间: 1984
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Johnson,HM;Torres,BA
通讯作者: Torres,BA