Relationship between Pulmonary Regurgitation and Ventriculo-Arterial Interactions in Patients with Post-Early Repair of Tetralogy of Fallot: Insights from Wave-Intensity Analysis.
Relationship between Pulmonary Regurgitation and Ventriculo-Arterial Interactions in Patients with Post-Early Repair of Tetralogy of Fallot: Insights from Wave-Intensity Analysis.
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DOI：
10.3390/jcm11206186
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发表时间：
2022-10-20
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究旨在探讨肺动脉瓣反流（PR）对法洛四联症（ToF）修复术后左心室-心室-动脉（VA）耦合的影响。假设PR严重程度增加导致主动脉波强度中的前向压缩波（FCW）峰值较小，因为右心室与左心室相互作用。心血管磁共振（CMR）衍生波强度分析的使用提供了不同PR程度患者之间的非侵入性比较。共研究了n = 201例患者，并比较了血流动力学和波强度数据。计算前向压缩波和前向扩张波的波强度峰值和面积作为心室功能的替代物。任何程度的PR都导致FCW峰显著降低。主动脉扩张性和FCW峰值之间存在相关性，这表明在也存在更僵硬的升主动脉的患者中存在不利的（VA）耦合。数据表明VA耦合受阻抗增加的影响。
This study aimed to investigate the effect of pulmonary regurgitation (PR) on left ventricular ventriculo–arterial (VA) coupling in patients with repaired tetralogy of Fallot (ToF). It was hypothesised that increasing PR severity results in a smaller forward compression wave (FCW) peak in the aortic wave intensity, because of right-to-left ventricular interactions. The use of cardiovascular magnetic resonance (CMR)-derived wave-intensity analysis provided a non-invasive comparison between patients with varying PR degrees. A total of n = 201 patients were studied and both hemodynamic and wave-intensity data were compared. Wave-intensity peaks and areas of the forward compression and forward expansion waves were calculated as surrogates of ventricular function. Any extent of PR resulted in a significant reduction in the FCW peak. A correlation was found between aortic distensibility and the FCW peak, suggesting unfavourable (VA) coupling in patients that also present stiffer ascending aortas. Data suggest that VA coupling is affected by increased impedance.
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影响因子：
2.2
作者：
Khir, AW;Zambanini, A;Parker, KH
通讯作者：
Parker, KH
DOI：
10.1016/s0022-5223(99)70214-x
发表时间：
1999-08-01
影响因子：
6
作者：
Oechslin, EN;Harrison, DA;Williams, WG
通讯作者：
Williams, WG
影响因子：
1.5
作者：
Ohte, N;Narita, H;Kimura, G
通讯作者：
Kimura, G
影响因子：
2.4
作者：
Feng, J.;Khir, A. W.
通讯作者：
Khir, A. W.
影响因子：
0.3
作者：
Ammash, Naser M;Dearani, Joseph A;Connolly, Heidi M
通讯作者：
Connolly, Heidi M