Influence of physical activity and nutrition on obesity-related immune function.
Influence of physical activity and nutrition on obesity-related immune function.
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DOI：
10.1155/2013/752071
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发表时间：
2013-11-07
影响因子：
--
通讯作者：
Ormsbee MJ
中科院分区：
文献类型：
--
作者：
Huang CJ;Zourdos MC;Jo E;Ormsbee MJ
检查肥胖期间免疫功能的研究表明，过度肥胖与导致病理的免疫反应受损有关。肥胖对免疫力的有害影响与脂肪细胞分泌分子产生的全身促炎症有关。这些包括炎症肽，例如 TNF-α、CRP 和 IL-6。因此，肥胖现在被定性为一种慢性低度全身炎症状态，这种状态与合并症的发生有很大关系。鉴于脂肪组织在炎症过程中的关键作用，尤其是在肥胖个体中，识别可能影响肥胖与免疫系统关系的生活方式因素成为一个重要的临床目标。例如，压力、体力活动和营养均已被证明是影响与肥胖状态相关的炎症特征的重要生活方式因素。因此，本综述的目的是综合评估生活方式因素，特别是心理压力、体力活动和营养对肥胖相关免疫功能的影响，特别关注炎症。
Research examining immune function during obesity suggests that excessive adiposity is linked to impaired immune responses leading to pathology. The deleterious effects of obesity on immunity have been associated with the systemic proinflammatory profile generated by the secretory molecules derived from adipose cells. These include inflammatory peptides, such as TNF-α, CRP, and IL-6. Consequently, obesity is now characterized as a state of chronic low-grade systemic inflammation, a condition considerably linked to the development of comorbidity. Given the critical role of adipose tissue in the inflammatory process, especially in obese individuals, it becomes an important clinical objective to identify lifestyle factors that may affect the obesity-immune system relationship. For instance, stress, physical activity, and nutrition have each shown to be a significant lifestyle factor influencing the inflammatory profile associated with the state of obesity. Therefore, the purpose of this review is to comprehensively evaluate the impact of lifestyle factors, in particular psychological stress, physical activity, and nutrition, on obesity-related immune function with specific focus on inflammation.
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