Tumor-induced disruption of proximal TCR-mediated signal transduction in tumor-infiltrating CD8+ lymphocytes inactivates antitumor effector phase.
Tumor-induced disruption of proximal TCR-mediated signal transduction in tumor-infiltrating CD8+ lymphocytes inactivates antitumor effector phase.
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DOI：
10.4049/jimmunol.1001157
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发表时间：
2010-12-15
期刊：
影响因子：
--
通讯作者：
Frey AB
中科院分区：
文献类型：
--
作者：
Vazquez-Cintron EJ;Monu NR;Frey AB
癌组织中Ag特异性活化的肿瘤浸润性CD8+ T细胞的存在证明肿瘤表达能够引发免疫应答的Ag。因此，一般来说，肿瘤逃避免疫介导的清除并不归因于免疫无知。然而，肿瘤浸润淋巴细胞在效应期功能上有缺陷，表明肿瘤诱导的免疫抑制可能是肿瘤逃逸的基础。由于溶胞颗粒的胞吐作用依赖于TCR介导的信号转导，因此肿瘤可能在肿瘤浸润性T细胞中诱导有缺陷的信号转导是合理的。在这篇综述中，我们考虑了抗肿瘤T细胞功能障碍的生化基础，重点是抑制性信号受体在限制肿瘤浸润淋巴细胞中TCR介导的信号传导中的作用。
The presence in cancer tissue of Ag-specific, activated tumor infiltrating CD8+ T cells proves that tumors express Ags capable of eliciting immune response. Therefore, in general, tumor escape from immune-mediated clearance is not attributable to immunological ignorance. However, tumor-infiltrating lymphocytes are defective in effector phase function, demonstrating tumor-induced immune suppression that likely underlies tumor escape. Since exocytosis of lytic granules is dependent upon TCR-mediated signal transduction, it is a reasonable contention that tumors may induce defective signal transduction in tumor infiltrating T cells. In this review, we consider the biochemical basis for antitumor T cell dysfunction, focusing on the role of inhibitory signaling receptors in restricting TCR-mediated signaling in tumor-infiltrating lymphocytes.
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影响因子：
4.4
作者：
Almand, B;Clark, JI;Gabrilovich, DI
通讯作者：
Gabrilovich, DI
DOI：
10.1073/pnas.0903497106
发表时间：
2009-08-25
影响因子：
11.1
作者：
Chen, Huan-Yuan;Fermin, Agnes;Liu, Fu-Tong
通讯作者：
Liu, Fu-Tong
影响因子：
30.5
作者：
Grohmann, U;Orabona, C;Puccetti, P
通讯作者：
Puccetti, P
影响因子：
4.4
作者：
Friedlein, Grzegorz;El Hage, Faten;Mami-Chouaib, Fathia
通讯作者：
Mami-Chouaib, Fathia
影响因子：
30.5
作者：
Blackburn, Shawn D.;Shin, Haina;Haining, W. Nicholas;Zou, Tao;Workman, Creg J.;Polley, Antonio;Betts, Michael R.;Freeman, Gordon J.;Vignali, Dario A. A.;Wherry, E. John
通讯作者：
Wherry, E. John