Centrocortin cooperates with centrosomin to organize Drosophila embryonic cleavage furrows.
Centrocortin cooperates with centrosomin to organize Drosophila embryonic cleavage furrows.
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中心皮质素与中心素合作，组织果蝇胚胎裂解。
DOI：
10.1016/j.cub.2009.04.037
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发表时间：
2009-06-09
期刊：
影响因子：
--
通讯作者：
Megraw TL
中科院分区：
文献类型：
--
作者：
Kao LR;Megraw TL
In the Drosophila early embryo the centrosome coordinates assembly of cleavage furrows. Currently, the molecular pathway that links the centrosome and the cortical microfilaments is unknown. In centrosomin (cnn) mutants, where the centriole forms but the centrosome pericentriolar material (PCM) fails to assemble, actin microfilaments are not organized into furrows at the syncytial cortex. While CNN is required for centrosome assembly and function, little is known of its molecular activities. Here, we show the novel protein Centrocortin (CEN), which associates with centrosomes and also with cleavage furrows in early embryos, is required for cleavage furrow assembly. CEN binds to CNN within CNN Motif 2 (CM2), a conserved 60 amino-acid domain at CNN’s C-terminus. The cnnB4 allele, which contains a missense mutation at a highly conserved residue within CM2, blocks the binding of CEN and disrupts cleavage furrow assembly. Together, these findings show that the C-terminus of CNN coordinates cleavage furrow formation through binding to CEN, providing a molecular link between the centrosome and cleavage furrow assembly.
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DOI：
10.1083/jcb.200704081
发表时间：
2007-08-27
期刊：
The Journal of cell biology
影响因子：
--
作者：
Lucas EP;Raff JW
通讯作者：
Raff JW
影响因子：
3.3
作者：
Zhang, Jiuli;Megraw, Timothy L.
通讯作者：
Megraw, Timothy L.
DOI：
10.1083/jcb.200712036
发表时间：
2008-07-28
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cao J;Albertson R;Riggs B;Field CM;Sullivan W
通讯作者：
Sullivan W
影响因子：
64.5
作者：
Lecuyer, Eric;Yoshida, Hideki;Krause, Henry M.
通讯作者：
Krause, Henry M.
影响因子：
3.3
作者：
Riggs, Blake;Fasulo, Barbara;Sullivan, William
通讯作者：
Sullivan, William