Defective placentation syndromes and autism spectrum disorder in the offspring: population-based cohort and sibling-controlled studies.
Defective placentation syndromes and autism spectrum disorder in the offspring: population-based cohort and sibling-controlled studies.
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DOI：
10.1007/s10654-022-00884-3
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发表时间：
2022-08
影响因子：
13.6
通讯作者：
Cnattingius, Sven
中科院分区：
文献类型：
--
作者：
Villamor, Eduardo;Susser, Ezra S.;Cnattingius, Sven
关键词：
缺陷胎盘形成是可能影响脑发育的多种综合征表现的基础，包括：1）胎盘脱垂，2）足月先兆子痫伴小于胎龄（SGA）婴儿，3）早产先兆子痫，和4）自发性早产。我们调查了这些缺陷性胎盘形成综合征与后代自闭症谱系障碍（ASD）发病率之间的关系。我们对2000-2016年在瑞典出生的1，645，455名无畸形单胎婴儿进行了一项基于人群的队列研究，这些婴儿使用国家登记册进行了长达17年的随访。我们使用校正的风险比（HR）和考克斯回归的95%置信区间（CI）比较了产前暴露于和未暴露于缺陷性胎盘形成综合征的儿童的ASD发生率。我们还对1，092，132名同胞进行了同胞对照分析。在中介分析中估计了这些综合征与独立于早产的ASD的关联。有23，810例ASD病例。在一般队列和同胞分析中，合并SGA的足月子痫前期母亲的儿童ASD的校正HR（95%CI）增加（分别为1.5 [1.3，1.9]和1.9 [1.1，3.3]），早产先兆子痫<34周（分别为1.8 [1.4，2.2]和4.2 [2.1，8.5]）和自发性极早产或极早产（≤31周）（分别为2.6 [2.2，3.0]和2.4 [1.5，3.8]）。仅在一般队列分析中，胎盘脱垂与ASD HR增加相关。先兆子痫和ASD之间的关联不能完全解释早产。总之，与胎盘形成缺陷相关的综合征与后代ASD发病率增加有关。
Defective placentation underlies diverse syndromic manifestations that could affect brain development including: 1) placental abruption, 2) term preeclampsia with a small-for-gestational age (SGA) infant, 3) preterm preeclampsia, and 4) spontaneous preterm birth. We investigated the relations between these defective placentation syndromes and the incidence of Autism Spectrum Disorder (ASD) in offspring. We conducted a population-based cohort study of 1,645,455 non-malformed singleton infants born in Sweden 2000–2016 who were followed for up to 17 years using national registers. We compared ASD rates for children prenatally exposed and unexposed to defective placentation syndromes with use of adjusted hazard ratios (HR) with 95% confidence intervals (CI) from Cox regression. We also conducted sibling-controlled analyses among 1,092,132 full siblings. The association of the syndromes with ASD independent of preterm birth was estimated in mediation analyses. There were 23,810 cases of ASD. In both general cohort and sibling analyses, adjusted HRs (95% CI) of ASD were increased in children of mothers with term preeclampsia combined with SGA (1.5 [1.3, 1.9] and 1.9 [1.1, 3.3], respectively), preterm preeclampsia <34 weeks (1.8 [1.4, 2.2] and 4.2 [2.1, 8.5], respectively), and spontaneous very or extremely preterm birth (≤31 weeks) (2.6 [2.2, 3.0] and 2.4 [1.5, 3.8], respectively). Placental abruption was associated with increased HR of ASD in general cohort analysis only. The association between preeclampsia and ASD was not fully explained by preterm birth. In conclusion, syndromes linked to defective placentation are associated with increased incidence of ASD in the offspring.
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影响因子：
2.8
作者：
Cnattingius, Sven;Wikstrom, Anna-Karin;Johansson, Kari
通讯作者：
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影响因子：
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DOI：
10.1016/j.bpobgyn.2010.10.012
发表时间：
2011-06-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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