EVALUATION OF THE CHELATING EFFECT OF METHANOLIC EXTRACT OF CORIANDRUM SATIVUM AND ITS FRACTIONS ON WISTAR RATS POISONED WITH LEAD ACETATE
EVALUATION OF THE CHELATING EFFECT OF METHANOLIC EXTRACT OF CORIANDRUM SATIVUM AND ITS FRACTIONS ON WISTAR RATS POISONED WITH LEAD ACETATE
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芫荽甲醇提取物及其部位对醋酸铅中毒Wistar大鼠的螯合作用评价
DOI：
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发表时间：
2017
影响因子：
--
通讯作者：
J. Morán
中科院分区：
文献类型：
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作者：
M. Téllez;Gabriela Mora;Iromi Marlen Ceniceros;Concepción García;C. O. Puente;María;L. Serrano;Rubén García Garza;J. Morán
背景：近年来，由于使用这种金属的行业加强了健康控制，铅中毒率有所下降。然而，它仍然是一个全球性的公共卫生问题。使用各种具有螯合性能的植物一直是当今的研究课题。在传统医学中，据说芫荽具有螯合作用，但没有科学证据支持这一事实。本研究旨在探讨芫荽甲醇提取物及其提取部位对铅中毒大鼠的螯合作用。材料与方法：本研究用50 mg/kg醋酸铅染毒雄性Wistar大鼠，并用50 mg/kg甲醇提取物及其组分进行治疗。将提取物及其级分给予四个治疗组。建立阳性和阴性对照。分析血红蛋白、红细胞压积和铅浓度;在对照组和给药组中对肝脏进行组织学评价。结果：芫荽甲醇提取物LD 50>1000 mg/dL。与阴性对照组相比，甲醇浸提液给药组的血红蛋白和红细胞压积水平存在显著差异。与阳性对照相比，处理组中的铅浓度显示出降低。组织的组织学评价显示，与呈现结构改变的阳性对照相比，甲醇提取物及其组分给药组的损伤较小。结论：芫荽提取物对铅中毒大鼠具有保护肝脏和降低铅浓度的作用。
Background: The rate of lead poisoning has decreased in recent years due to increased health control in industries that use this metal. However, it is still a public health problem worldwide. The use of various plants with chelating properties has been a topic of research today. In traditional medicine, it is said that Coriandrum sativum has chelating properties, but there is no scientific evidence to support this fact. The purpose of this research is to evaluate the chelating effect of methanol extract of coriander and its fractions on Wistar rats intoxicated with lead. Materials and Methods: In this research, male Wistar rats were poisoned with 50 mg/kg of lead acetate and treated with 50 mg/kg of methanol extract and its fractions. The extract and its fractions were administered to four treatment groups. Positive and negative controls were established. Hemoglobin, hematocrit and lead concentrations were analyzed; liver was evaluated histologically in control and treatment groups. Results: The methanol extract of coriander presented a LD50 >1000 mg/dL. The group administered with the methanol extract showed significant difference in the levels of hemoglobin and hematocrit compared to the negative control group. Lead concentration in treatment groups showed a decrease compared to the positive control. Histological evaluation of tissue showed less damage in groups administered with methanolic extract and its fractions compared to the positive control which presented structural alterations. Conclusion: Coriander extracts protect liver and lower lead concentration in rats intoxicated with lead in contrast to the positive control group.
影响因子：
2.7
作者：
MEYER, BN;FERRIGNI, NR;MCLAUGHLIN, JL
通讯作者：
MCLAUGHLIN, JL