Characteristics of gastrointestinal symptoms and function following endoscopic submucosal dissection and treatment of the gastrointestinal symptoms using rikkunshito
Characteristics of gastrointestinal symptoms and function following endoscopic submucosal dissection and treatment of the gastrointestinal symptoms using rikkunshito
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内镜粘膜下剥离术后胃肠道症状和功能的特点及六君子汤治疗胃肠道症状
DOI：
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发表时间：
2013
影响因子：
2.7
通讯作者：
K. Nakao
中科院分区：
文献类型：
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作者：
Ryohei Uehara;H. Isomoto;H. Minami;N. Yamaguchi;K. Ohnita;T. Ichikawa;F. Takeshima;S. Shikuwa;K. Nakao
本研究的目的是研究胃镜下黏膜下剥离术(ESD)后的胃肠道(GI)症状和胃排空情况，并评价一种新的使用日本传统草药利空石藤的治疗策略。作为第一步研究的一部分，在ESD后6-8天评估胃肠道症状和胃排空。在第一步研究中，将两组在质子泵抑制剂(PPI；PPI单一治疗组，n=5)或PPI+利空施托组(PPI+Rikunshito，n=8)治疗4周和8周后的胃肠症状评定量表(GSRs)评分与基线值进行比较。大多数患者在ESD后出现腹痛和便秘。胃排空后6~8d的平均T-max为75.4±13.6min，显著长于正常对照组的43.9±10.3min。在Step 2研究中，只有PPI+Rikunshito组在治疗8周后GSRs总分显著改善。总而言之，ESD影响胃排空，并与上消化道症状(如腹痛和消化不良)的发生率增加有关。Rikunshito可能作为一种新的辅助治疗药物用于治疗ESD患者的胃肠道症状。
The aim of the present study was to investigate the gastrointestinal (GI) symptoms and gastric emptying following endoscopic submucosal dissection (ESD), as well as to evaluate a novel treatment strategy using rikkunshito, a traditional Japanese herbal medicine. GI symptoms and gastric emptying were evaluated 6–8 days after ESD as part of the Step I study. In the Step 1 study, the Gastrointestinal Symptom Rating Scale (GSRS) scores of the two groups after 4 and 8 weeks of treatment with either a proton pump inhibitor (PPI; PPI monotreatment group, n=5) or a PPI plus rikkunshito (PPI + rikkunshito group, n=8) were compared against baseline values. Abdominal pain and constipation occurred in the majority of patients after ESD. The mean T-max 6–8 days after gastric emptying was 75.4±13.6 min, which was significantly longer compared with that reported in healthy subjects (43.9±10.3 min). In the Step 2 study, the total GSRS score was significantly improved only in the PPI + rikkunshito group after 8 weeks of treatment. In conclusion, ESD affects gastric emptying and is associated with an increased incidence of upper GI symptoms such as abdominal pain and indigestion. Rikkunshito may be useful as a novel supporting therapeutic drug for the treatment of GI symptoms in patients who have undergone ESD.
影响因子：
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作者：
CAMILLERI, M;MALAGELADA, JR;ZINSMEISTER, AR
通讯作者：
ZINSMEISTER, AR