Checkpoint blockade-based immunotherapy in the context of tumor microenvironment: Opportunities and challenges.
Checkpoint blockade-based immunotherapy in the context of tumor microenvironment: Opportunities and challenges.
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肿瘤微环境背景下基于检查点阻断的免疫治疗：机遇与挑战
DOI：
10.1002/cam4.1722
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发表时间：
2018-09
期刊：
影响因子：
4
通讯作者：
Jiao S
中科院分区：
文献类型：
--
作者：
Duan J;Wang Y;Jiao S
肿瘤细胞与肿瘤微环境（TME）之间动态的互利相互作用促进了实体瘤的进展和转移。癌症免疫疗法正成为多种癌症的一种主要治疗模式。尽管免疫疗法，尤其是免疫检查点抑制剂的使用，已经取得了临床成功，但只有少数患者表现出持久的反应。目前正在进行旨在确定可用于预测免疫疗法反应的合适生物标志物和免疫特征的临床研究。结合针对癌症 - 免疫相互作用定制的治疗策略旨在提高患者持久临床反应的比率。根据肿瘤微环境建立合理的肿瘤分类策略对于改善癌症免疫疗法至关重要。在当前的综述中，提出了一种改良的肿瘤微环境分类方法，并且未来需要通过对大量患者队列进行详细和综合的分子特征分析来优化肿瘤微环境分类。
A dynamic and mutualistic interaction between tumor cells and tumor microenvironment (TME) promotes the progression and metastasis of solid tumors. Cancer immunotherapy is becoming a major treatment paradigm for a variety of cancers. Although immunotherapy, especially the use of immune checkpoint inhibitors, has achieved clinical success, only a minority of patients exhibits durable responses. Clinical studies directed at identifying appropriate biomarkers and immune profiles that can be used to predict immunotherapy responses are presently being conducted. Combining treatment strategies tailored to cancer‐immune interactions are designed to increase the rate of durable clinical response in patients. It is essential to establish a reasonable tumor classification strategy according to TME to improve cancer immunotherapy. In the current review, a modified classification of TME is proposed, and optimization of TME classification is needed through detailed and integrated molecular characterization of large patient cohorts in the future.
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影响因子：
5.5
作者：
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