Mosquitocidal toxins of bacilli and their genetic manipulation for effective biological control of mosquitoes.
Mosquitocidal toxins of bacilli and their genetic manipulation for effective biological control of mosquitoes.
复制标题
杆菌的杀蚊毒素及其基因操作，用于有效地生物控制蚊子。
DOI：
--
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Jian
中科院分区：
文献类型：
--
作者：
Alan G. Porter;E. Davidson;Jian
The identification, cloning, and characterization of protein toxins from various species of bacilli have demonstrated the existence of mosquitocidal toxins with different structures, mechanisms of action, and host ranges. A start has been made in understanding the polypeptide determinants of toxicity and insecticidal activity, and the purification of toxins from recombinant organisms may lead to the elucidation of their X-ray crystal structures and the cloning of brush border membrane receptors. The results of cloning mosquitocidal toxins in heterologous microorganisms show the potential of expanding the range of susceptible mosquito species by combining several toxins of different host specificity in one cell. Toxins have been expressed in new microorganisms with the potential for increasing potency by persisting at the larval feeding zone. The powerful tools of bacterial genetics are being applied to engineer genetically stable, persistent toxin expression and expand the insecticidal host ranges of Bacillus sphaericus and Bacillus thuringiensis strains. These techniques, together with modern formulation technology, should eventually lead to the construction of mosquitocidal microorganisms which are effective enough to have a real impact on mosquito-borne diseases.
登录
查看更多内容
使用可传播质粒作为新月柄杆菌中的克隆载体。
影响因子：
3.5
作者：
Schoenlein,PV;Gallman,LM;Ely,B
通讯作者：
Ely,B
球形芽孢杆菌杀幼虫蛋白的相互作用。
影响因子：
2.8
作者：
Davidson,EW;Oei,C;Meyer,M;Bieber,AL;Hindley,J;Berry,C
通讯作者：
Berry,C
用于在杀虫生物 Bacillus sphaericus 1593 中克隆的质粒载体的构建和表征。
影响因子：
2.6
作者：
Norton,NB;Orzech,KA;BurkeJr,WF
通讯作者：
BurkeJr,WF
将单拷贝序列引入大肠杆菌染色体：应用于基因和操纵子融合。
影响因子：
3.5
作者：
Resnik,E;LaPorte,DC
通讯作者：
LaPorte,DC
DOI：
10.1016/s0021-9258(18)45879-6
发表时间：
1992-02
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Dong Wu;A. Aronson
通讯作者：
Dong Wu;A. Aronson