Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases.
Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases.
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DOI：
10.1186/s41232-021-00164-9
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发表时间：
2021-05-03
影响因子：
8.1
通讯作者：
Tanaka Y
中科院分区：
文献类型：
--
作者：
Hao H;Nakayamada S;Tanaka Y
滤泡辅助性T细胞参与刺激生发中心（GC）形成并支持B细胞分化和自身抗体产生。然而，T滤泡调节（Tfr）细胞抑制B细胞活化。由于Tfr细胞数量和功能的改变导致GC反应和自身抗体反应失调，靶向Tfr细胞可能有利于治疗自身免疫性疾病。Tfr细胞的分化是一个多阶段和多因素的过程，有各种正和负调节因子。因此，了解调节Tfr细胞生成的信号对于靶向治疗的发展至关重要。在这篇综述中，我们讨论了最近的研究，阐明了Tfr细胞在自身免疫性疾病中的作用，并调查了Tfr细胞分化的调节剂。此外，突出了针对Tfr细胞的潜在免疫疗法。
T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysregulated GC reaction and autoantibody response, targeting Tfr cells may benefit the treatment of autoimmune diseases. Differentiation of Tfr cells is a multistage and multifactorial process with various positive and negative regulators. Therefore, understanding the signals regulating Tfr cell generation is crucial for the development of targeted therapies. In this review, we discuss recent studies that have elucidated the roles of Tfr cells in autoimmune diseases and investigated the modulators of Tfr cell differentiation. Additionally, potential immunotherapies targeting Tfr cells are highlighted.
急性呼吸窘迫综合征发作期间，滤泡 T 调节细胞浸润人体气道并调节 B 调节细胞的发育
影响因子：
4.4
作者：
Li H;Zhou R;Wang C;Li Y;Zheng G;Jiang S;Dong T;Bai J;Xu S
通讯作者：
Xu S