Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack.
Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack.
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DOI：
10.1111/j.1538-7836.2008.02902.x
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发表时间：
2008-04
影响因子：
10.4
通讯作者：
Lowe, G. D. O.
中科院分区：
文献类型：
--
作者：
Crawley, J. T. B.;Lane, D. A.;Woodward, M.;Rumley, A.;Lowe, G. D. O.
背景资料：具有血小板反应蛋白1型基序的去整合素和金属蛋白酶成员13（ADAMTS-13）可影响血管性血友病因子（VWF）水平，从而影响心肌梗死（MI）的风险。此外，ADAMTS-13影响小鼠模型中的止血栓形成。因此，我们在格拉斯哥MI研究（GLAMIS）中研究了它们的相关性。方法与结果：我们测量ADAMTS-13和VWF抗原水平的ELISA储存血浆从病例对照研究的466例心肌梗死病例和484名年龄和性别匹配的对照，从相同的北格拉斯哥人口。ADAMTS-13与VWF水平在病例组和对照组中均无相关性。ADAMTS-13水平与血清胆固醇、甘油三酯和体重指数呈正相关，与高密度脂蛋白胆固醇呈负相关。VWF水平与年龄、纤维蛋白原和C反应蛋白相关。在包括危险因素的多变量分析中，VWF与MI风险呈正相关，ADAMTS-13与MI风险呈负相关。这些协会是相互独立的。仅在多变量分析中观察到ADAMTS-13与MI风险的相关性。结论：在这项研究中，VWF和ADAMTS-13水平不相关，并显示与MI风险的相关性方向相反，但强度相似。ADAMTS-13与MI的关联受脂质水平的影响，因此需要进一步研究。
Background: A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS-13) may influence von Willebrand factor (VWF) levels and consequently the risk of myocardial infarction (MI). Moreover, ADAMTS-13 influences hemostatic plug formation in mouse models. We therefore studied their associations in the Glasgow MI Study (GLAMIS). Methods and results: We measured ADAMTS-13 and VWF antigen levels by ELISAs in stored plasma from a case–control study of 466 MI cases and 484 age- and sex-matched controls from the same north Glasgow population. There was no correlation between ADAMTS-13 and VWF levels in cases or controls. ADAMTS-13 levels correlated positively with serum cholesterol and triglycerides and body mass index, and negatively with high-density lipoprotein-cholesterol. VWF levels correlated with age, fibrinogen and C-reactive protein. In multivariable analyses including risk factors, VWF correlated positively with risk of MI, and ADAMTS-13 correlated negatively with risk of MI. These associations were independent of each other. The association of ADAMTS-13 with risk of MI was observed only in multivariable analysis. Conclusions: VWF and ADAMTS-13 levels were not associated in this study, and showed associations with MI risk in opposite directions but of similar strength. The association of ADAMTS-13 with MI is influenced by lipid levels, and consequently requires further investigation.
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影响因子：
10.4
作者：
Lowe, GDO;Woodward, M;Nieuwenhuizen, W
通讯作者：
Nieuwenhuizen, W
影响因子：
20.3
作者：
Chion, Chan K. N. K.;Doggen, Carine J. M.;Rosendaal, Frits R.
通讯作者：
Rosendaal, Frits R.
影响因子：
20.3
作者：
Fujikawa, K;Suzuki, H;Chung, D
通讯作者：
Chung, D
影响因子：
20.3
作者：
Tsai, HM
通讯作者：
Tsai, HM
影响因子：
2.8
作者：
Matsukawa, Masakazu;Kaikita, Koichi;Ogawa, Hisao
通讯作者：
Ogawa, Hisao