The UCSD shortness of breath questionnaire has longitudinal construct validity in idiopathic pulmonary fibrosis.
The UCSD shortness of breath questionnaire has longitudinal construct validity in idiopathic pulmonary fibrosis.
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DOI：
10.1016/j.rmed.2012.06.018
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发表时间：
2012-10
影响因子：
4.3
通讯作者：
Fairclough, Diane
中科院分区：
文献类型：
--
作者：
Swigris, Jeffrey J.;Han, Meilan;Vij, Rekha;Noth, Imre;Eisenstein, Eric L.;Anstrom, Kevin J.;Brown, Kevin K.;Fairclough, Diane
特发性肺纤维化（IPF）是一种进行性间质性肺疾病，常导致致残性呼吸困难。在特发性肺纤维化和其他肺部疾病中，患者报告的结局（PRO）--旨在从患者的角度收集信息的问卷--可以确定治疗是否影响呼吸困难或对患者有意义的其他结局。在PRO可以自信地用作纵向试验中的结局指标之前，研究必须证明PRO能够捕获目标人群随时间的变化。本研究的目的是检查UCSD呼吸短促问卷是否适用于IPF患者。我们使用来自特发性肺纤维化运动能力西地那非试验（STEP-IPF）的数据进行分析，检查UCSD评分与基线和随时间推移的五项外部指标（锚点）之间的相关性。评估因子包括来自圣乔治呼吸问卷（SGRQ-A）的活动域、来自SF-36（SF 36-PF）的身体功能域、用力肺活量（FVC）、肺一氧化碳弥散量（DLCO）和定时步行试验（6 MWD）中的步行距离。使用线性回归模型来检查UCSD分数与锚点之间随时间的关系。基线时，UCSD评分与FVC预测百分比（-0.21，p=0.005）和DLCO预测百分比（-0.20，p=0.008）弱相关，与6 MWD中度相关（-0.39，p<0.0001），与SGRQ-A（0.79，p<0.0001）和SF 36-PF（-0.72，p<0.0001）强相关。UCSD评分随时间的变化与FVC的变化相关（估计值=2.54，标准误[SE]=1.23，p=0.04），SGRQ-A（估计值=7.94，SE=1.11，p<0.0001），SF 36-PF（估计值=6.00，SE=1.13，p<0.0001）和6 MWD（估计值=4.23，SE=1.18，p=0.0004），但不是DLCO（估计值=0.33，SE=1.33，p=0.80）。这些结果支持UCSD评估IPF患者呼吸困难随时间变化的有效性。
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease that often causes disabling dyspnea. In IPF and other lung diseases, patient-reported outcomes (PROs)—questionnaires designed to gather information from the patient's perspective—can determine whether therapies affect dyspnea or other outcomes meaningful to patients. Before a PRO can be used confidently as an outcome measure in a longitudinal trial, studies must demonstrate the PRO's ability to capture change over time in the target population. Our goal in this study was to examine whether the UCSD Shortness of Breath Questionnaire does so in patients with IPF. We used data from the Sildenafil Trial of Exercise Performance in Idiopathic Pulmonary Fibrosis (STEP-IPF) to perform analyses that examined associations between UCSD scores and five external measures (anchors) at baseline and over time. Anchors included the Activity domain from St. George's Respiratory Questionnaire (SGRQ-A), the Physical Functioning domain from the SF-36 (SF36-PF), forced vital capacity (FVC), diffusing capacity of the lung for carbon monoxide (DLCO), and distance walked during a timed walk test (6MWD). Linear regression models were used to examine relationships between UCSD scores and anchors over time. At baseline, UCSD scores were weakly correlated with percent predicted FVC (−0.21, p=0.005) and percent predicted DLCO (−0.20, p=0.008), moderately correlated with 6MWD (−0.39, p<0.0001) and strongly correlated with SGRQ-A (0.79, p<0.0001) and SF36-PF (−0.72, p<0.0001). Change over time in UCSD scores was associated with change in FVC (estimate=2.54, standard error [SE]=1.23, p=0.04), SGRQ-A (estimate=7.94, SE=1.11, p<0.0001), SF36-PF (estimate=6.00, SE=1.13, p<0.0001), and 6MWD (estimate=4.23, SE=1.18, p=0.0004) but not DLCO (estimate=0.33, SE=1.33, p=0.80). These results support the validity of the UCSD to assess change in dyspnea over time in patients with IPF.
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影响因子：
4.3
作者：
Swigris, Jeffrey J.;Brown, Kevin K.;Behr, Juergen;du Bois, Roland M.;King, Talmadge E.;Raghu, Ganesh;Wambold, Frederick S.
通讯作者：
Wambold, Frederick S.
DOI：
10.1007/bf00435438
发表时间：
1992-02-01
期刊：
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
影响因子：
--
作者：
Hays, R D;Hadorn, D
通讯作者：
Hadorn, D
影响因子：
3.5
作者：
Revicki, DA;Osoba, D;Rothman, M
通讯作者：
Rothman, M
影响因子：
168.9
作者：
Noble, Paul W.;Albera, Carlo;du Bois, Roland M.
通讯作者：
du Bois, Roland M.
影响因子：
4.3
作者：
Nishiyama, O;Taniguchi, H;Nishimura, K
通讯作者：
Nishimura, K