Altered White Matter Microstructure in Herpes Zoster and Postherpetic Neuralgia Determined by Automated Fiber Quantification.
Altered White Matter Microstructure in Herpes Zoster and Postherpetic Neuralgia Determined by Automated Fiber Quantification.
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DOI：
10.3390/brainsci12121668
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发表时间：
2022-12-04
期刊：
影响因子：
3.3
通讯作者：
Jiang, Jian
中科院分区：
文献类型：
--
作者：
Wu, Ying;Gu, Lili;Hong, Shunda;Li, Jiahao;Yang, Jiaojiao;Xiong, Jiaxin;Lv, Huiting;Jiang, Jian
本研究旨在探讨带状疱疹（HZ）和带状疱疹后神经痛（PHN）患者白质微结构的变化，并估计这些变化与临床数据的相关性。弥散张量成像（DTI）数据来自33名HZ患者，32名PHN患者和35名匹配良好的健康对照（hc）。随后，通过自动纤维定量（AFQ）对这些数据进行分析，以准确定位白质微观结构的变化。与hc相比，HZ和PHN患者的纤维束弥散特性均有较大范围的改变。HZ患者主要表现为左侧上纵束（SLF）的变化，而PHN患者主要表现为左侧额枕下束的变化。与HZ患者相比，PHN患者的双侧SLF和左侧皮质脊髓束发生改变。此外，与HZ患者相比，PHN患者表现出更广泛的白质改变趋势；此外，在PHN患者中，左扣带的变化与情绪变化和疾病持续时间显著相关。这些发现可能有助于阐明从HZ到PHN的转变，并为PHN难治性神经性疼痛的原因提供新的思路。
This study aimed to explore changes in the white matter microstructure in herpes zoster (HZ) and postherpetic neuralgia (PHN) patients and to estimate the correlation of these changes with clinical data. Diffusion tensor imaging (DTI) data were collected from 33 HZ patients, 32 PHN patients, and 35 well-matched healthy controls (HCs). Subsequently, these data were analyzed by automated fiber quantification (AFQ) to accurately locate alterations in the white matter microstructure. Compared with HCs, HZ and PHN patients both showed a wide range of changes in the diffusion properties of fiber tracts. HZ patients exhibited changes primarily in the left superior longitudinal fasciculus (SLF), whereas PHN patients predominantly exhibited changes in the left inferior fronto-occipital fasciculus. The bilateral SLF and the left corticospinal tract were altered in the PHN patients compared with HZ patients. In addition, PHN patients showed a trend toward more expansive white matter alterations compared with those observed in HZ patients; additionally, in PHN patients, changes in the left cingulum cingulate were significantly correlated with changes in emotion and the duration of disease. These findings may help to elucidate the transformation from HZ to PHN and provide new ideas regarding the reasons for intractable neuropathic pain in PHN.
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