The imaginary part of coherency in autism: differences in cortical functional connectivity in preschool children.
The imaginary part of coherency in autism: differences in cortical functional connectivity in preschool children.
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DOI：
10.1371/journal.pone.0075941
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Shanker S
中科院分区：
文献类型：
--
作者：
García Domínguez L;Stieben J;Pérez Velázquez JL;Shanker S
认知产生于不同功能脑区活动的短暂整合和分离。自闭症谱系障碍（ASD），其中包括广泛的发育障碍，已被假定为与协调活动的皮质和皮质下动力学的问题，通常涉及增强的本地，但减少了整合领域的长期协调。在本文中，我们挑战这个想法，提出了一个相对较大的人口ASD儿童和年龄匹配的控制过程中的面部处理任务的结果。在大多数探索的领域中，ASD儿童表现出增强的同步性，尽管更精细的细节揭示了取决于时间，频率和大脑部位的特定同步性增强/减少。我们的研究结果是来自使用的虚部的一致性，这是不容易体积传导伪影的措施，因此提出了一个可靠的图片协调的大脑活动。我们还提出了证据表明，这种措施是一个很好的候选人，以提供功能，在建立一个分类器，作为一个潜在的生物标志物自闭症。
Cognition arises from the transient integration and segregation of activity across functionally distinct brain areas. Autism Spectrum Disorders (ASD), which encompass a wide range of developmental disabilities, have been presumed to be associated with a problem in cortical and sub-cortical dynamics of coordinated activity, often involving enhanced local but decreased long range coordination over areas of integration. In this paper we challenge this idea by presenting results from a relatively large population of ASD children and age-matched controls during a face-processing task. Over most of the explored domain, children with ASD exhibited enhanced synchronization, although finer detail reveals specific enhancement/reduction of synchrony depending on time, frequency and brain site. Our results are derived from the use of the imaginary part of coherency, a measure which is not susceptible to volume conduction artifacts and therefore presents a credible picture of coordinated brain activity. We also present evidence that this measure is a good candidate to provide features in building a classifier to be used as a potential biomarker for autism.
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