The role of lipid-modified proteins in cell wall synthesis and signaling.
The role of lipid-modified proteins in cell wall synthesis and signaling.
复制标题
脂类修饰蛋白在细胞壁合成和信号传递中的作用。
DOI：
10.1093/plphys/kiad491
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发表时间：
2023-12-30
期刊：
影响因子：
7.4
通讯作者：
Turner, Simon
中科院分区：
文献类型：
--
作者：
Quinn, Oliver;Kumar, Manoj;Turner, Simon
植物细胞壁是一种复杂的、动态的细胞外基质。植物初生细胞壁是抵御病原体的第一道防线，并调节细胞的扩张。特化细胞存款一个次生细胞壁，提供支持和允许水运输。细胞壁的组成和组织因细胞类型和物种而异，有助于其正常功能所需的可延伸性，刚度和疏水性。最近，许多参与细胞壁的生物合成、维持和重塑的蛋白质已被鉴定为用脂质进行后修饰。这些修饰表现出不同的结构，并在不同的位点连接到蛋白质上，这定义了每种脂质修饰所起的特定作用。相对疏水的脂质部分的引入促进蛋白质与膜的相互作用，并且可以充当分选信号，允许靶向递送至质膜区域并分泌至质外体中。脂质修饰的破坏会导致细胞壁成分的异常沉积和响应应激的有缺陷的细胞壁重塑，这证明了这些修饰的本质。虽然知道很多关于哪些蛋白质具有脂质修饰，许多问题仍然存在关于脂质驱动的膜结构域的本地化和脂质异质性的蛋白质功能在细胞壁代谢的贡献。在这次更新中，我们强调了脂质修饰对参与植物细胞壁形成和维持的蛋白质的贡献，重点是添加糖基磷脂酰肌醇锚，N-肉豆蔻酰化，异戊二烯化和S-酰化。
The plant cell wall is a complex and dynamic extracellular matrix. Plant primary cell walls are the first line of defense against pathogens and regulate cell expansion. Specialized cells deposit a secondary cell wall that provides support and permits water transport. The composition and organization of the cell wall varies between cell types and species, contributing to the extensibility, stiffness, and hydrophobicity required for its proper function. Recently, many of the proteins involved in the biosynthesis, maintenance, and remodeling of the cell wall have been identified as being post-translationally modified with lipids. These modifications exhibit diverse structures and attach to proteins at different sites, which defines the specific role played by each lipid modification. The introduction of relatively hydrophobic lipid moieties promotes the interaction of proteins with membranes and can act as sorting signals, allowing targeted delivery to the plasma membrane regions and secretion into the apoplast. Disruption of lipid modification results in aberrant deposition of cell wall components and defective cell wall remodeling in response to stresses, demonstrating the essential nature of these modifications. Although much is known about which proteins bear lipid modifications, many questions remain regarding the contribution of lipid-driven membrane domain localization and lipid heterogeneity to protein function in cell wall metabolism. In this update, we highlight the contribution of lipid modifications to proteins involved in the formation and maintenance of plant cell walls, with a focus on the addition of glycosylphosphatidylinositol anchors, N-myristoylation, prenylation, and S-acylation.
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影响因子：
4.6
作者：
Chang HY;Cheng TH;Wang AH
通讯作者：
Wang AH
影响因子：
14.8
作者：
Dekker, Frank J.;Rocks, Oliver;Waldmann, Herbert
通讯作者：
Waldmann, Herbert
影响因子：
7.4
作者：
Bashline, Logan;Li, Shundai;Gu, Ying
通讯作者：
Gu, Ying
影响因子：
5.1
作者：
Hemsley, Piers A;Taylor, Laura;Grierson, Claire S
通讯作者：
Grierson, Claire S
DOI：
10.3390/plants12010008
发表时间：
2022-12-20
期刊：
Plants (Basel, Switzerland)
影响因子：
--
作者：
Stroppa N;Onelli E;Moreau P;Maneta-Peyret L;Berno V;Cammarota E;Ambrosini R;Caccianiga M;Scali M;Moscatelli A
通讯作者：
Moscatelli A