Kaumoebavirus, a New Virus That Clusters with Faustoviruses and Asfarviridae.

Kaumoebavirus, a New Virus That Clusters with Faustoviruses and Asfarviridae.
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DOI:
10.3390/v8110278
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发表时间:
2016-10-28
期刊:
Viruses
影响因子:
--
通讯作者:
La Scola B
La Scola B
中科院分区:
其他
文献类型:
--
作者:
Bajrai LH;Benamar S;Azhar EI;Robert C;Levasseur A;Raoult D;La Scola B

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在这项研究中,我们报告了从沙特阿拉伯吉达南部地区的污水中分离到一种新的巨型病毒,该病毒在形态和基因组上与福斯特病毒相似。这种新的巨型病毒被命名为KaumoebaVirus,是通过与Vermaoeba vermiformis共培养获得的,Vermaoeba vermiformis是一种被认为对人类健康和环境特别感兴趣的变形体原生动物。这种新病毒具有约250 nm的二十面体衣壳和350,731个碱基的DNA基因组长度。Kaumoebav病毒基因组编码密度为86%,对应465个基因。这些基因中的大多数(59%)与建议的巨病毒目成员的基因密切相关,其蛋白与巨病毒目其他成员的最佳匹配是镰刀病毒(43%)和阿斯法尔病毒(23%)。不出所料,系统发育重建将KaumoebaVirus定位为FaustoVirus和AsfarVirus的远亲。
In this study, we report the isolation of a new giant virus found in sewage water from the southern area of Jeddah (Saudi Arabia), with morphological and genomic resemblance to Faustoviruses. This new giant virus, named Kaumoebavirus, was obtained from co-culture with Vermamoeba vermiformis, an amoeboid protozoa considered to be of special interest to human health and the environment. This new virus has ~250 nm icosahedral capsids and a 350,731 bp DNA genome length. The genome of Kaumoebavirus has a coding density of 86%, corresponding to 465 genes. Most of these genes (59%) are closely related to genes from members of the proposed order Megavirales, and the best matches to its proteins with other members of the Megavirales are Faustoviruses (43%) and Asfarviruses (23%). Unsurprisingly, phylogenetic reconstruction places Kaumoebavirus as a distant relative of Faustoviruses and Asfarviruses.
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