Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets.
Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets.
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DOI：
10.1016/j.cmet.2018.02.007
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发表时间：
2018-03-06
期刊：
影响因子：
29
通讯作者：
Longhi MP
中科院分区：
文献类型：
--
作者：
Macdougall CE;Wood EG;Loschko J;Scagliotti V;Cassidy FC;Robinson ME;Feldhahn N;Castellano L;Voisin MB;Marelli-Berg F;Gaston-Massuet C;Charalambous M;Longhi MP
内脏脂肪组织（VAT）在协调全身能量稳态中具有多种作用。此外，VAT现在被认为是一个免疫位点，含有一系列先天性和适应性免疫细胞，在免疫监视和宿主防御中起直接作用。我们报告说，传统的树突状细胞（cDCs）在增值税获得耐受性表型通过上调参与脂肪细胞分化的途径。虽然cDC 1 DC中Wnt/β-连环蛋白途径的激活诱导IL-10产生，但cDC 2 DC中PPARγ途径的上调直接抑制其激活。结合起来，它们促进体内抗炎环境，延迟肥胖诱导的慢性炎症和胰岛素抵抗的发作。在长期营养过剩的情况下，脂肪细胞生物学的变化减少了β-catenin和PPARγ的活化，从而导致VAT炎症。VAT-cDC通过上调脂肪细胞相关通路获得致耐受性表型。cDC亚群中β-连环蛋白和PPARγ的活化促进抗炎性VAT-Combined，they delay onset of obesity-induced inflammation and insulin resistance。报道了控制内脏脂肪组织中传统树突状细胞免疫功能的关键机制。常规树突状细胞中脂肪细胞相关途径的上调促进了稳态条件下内脏脂肪组织中的抗炎表型，并延迟了肥胖诱导的炎症和胰岛素抵抗的发生。
Visceral adipose tissue (VAT) has multiple roles in orchestrating whole-body energy homeostasis. In addition, VAT is now considered an immune site harboring an array of innate and adaptive immune cells with a direct role in immune surveillance and host defense. We report that conventional dendritic cells (cDCs) in VAT acquire a tolerogenic phenotype through upregulation of pathways involved in adipocyte differentiation. While activation of the Wnt/β-catenin pathway in cDC1 DCs induces IL-10 production, upregulation of the PPARγ pathway in cDC2 DCs directly suppresses their activation. Combined, they promote an anti-inflammatory milieu in vivo delaying the onset of obesity-induced chronic inflammation and insulin resistance. Under long-term over-nutrition, changes in adipocyte biology curtail β-catenin and PPARγ activation, contributing to VAT inflammation. VAT-cDCs acquire a tolerogenic phenotype by upregulating adipocyte-related pathways Activation of β-catenin and PPARγ in cDC subsets promotes anti-inflammatory VAT Combined, they delay the onset of obesity-induced inflammation and insulin resistance Chronic over-nutrition curtails β-catenin and PPARγ pathways, fueling cDC activation Macdougall et al. report key mechanisms that control the immune function of conventional dendritic cells in visceral adipose tissue. The upregulation of adipocyte-related pathways in conventional dendritic cells promotes an anti-inflammatory phenotype in visceral adipose tissue under homeostatic conditions and delays the onset of obesity-induced inflammation and insulin resistance.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
10.9
作者：
Christodoulides, Constantinos;Lagathu, Claire;Sethi, Jaswinder K.;Vidal-Puig, Antonio
通讯作者：
Vidal-Puig, Antonio
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
32.4
作者：
Baratin, Myriam;Foray, Chloe;Lawrence, Toby
通讯作者：
Lawrence, Toby
DOI：
10.1016/j.tem.2011.07.003
发表时间：
2011-11
期刊：
Trends in endocrinology and metabolism: TEM
影响因子：
--
作者：
Iacobellis G;Bianco AC
通讯作者：
Bianco AC