Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort.
Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort.
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DOI：
10.1002/alz.12367
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Yaffe K
中科院分区：
文献类型：
--
作者：
Zeki Al Hazzouri A;Vittinghoff E;Hoang T;Golden SH;Fitzpatrick AL;Zhang A;Grasset L;Yaffe K
研究成年早期体重指数与男性和女性痴呆症发病率之间的独立关联。我们从心血管健康研究和健康、老龄化和身体成分研究中研究了5104名老年人。我们使用具有完整成人寿命覆盖范围和先前建立的方法的合并父母队列来计算成年期早期和中年BMI。痴呆症是通过神经心理测试、医疗记录和痴呆症相关药物使用等标准来确定的。采用合并Logistic回归模型。与成年早期BMI正常的女性相比，超重(OR=1.8；95%CI=1.31-2.54)和肥胖(OR=2.45；95%CI=1.47-4.06)的女性患痴呆症的几率更高，与中晚期BMI无关。在男性身上也观察到了类似的关系。随着美国成年人中肥胖流行的日益严重，旨在减少痴呆症的努力可能需要在生命过程的早期就开始预防和治疗肥胖。
To examine the independent association of BMI in early adulthood with dementia incidence among men and women. We studied 5,104 older adults from the Cardiovascular Health Study and the Health, Aging, and Body Composition study. We imputed early adulthood and midlife BMI using a pooled parent cohort with complete adult lifespan coverage and previously established methods. Dementia was ascertained using criteria such as neuropsychological test battery, medical records, and dementia-related drug use. Pooled logistic regression models were used. Compared to women with normal BMI in early adulthood, the odds of dementia were higher among both overweight (OR=1.8; 95%CI=1.31–2.54) and obese (OR=2.45; 95%CI=1.47–4.06) women, independent of mid and late life BMI. Similar relationship was observed in men. With the growing obesity epidemic among US adults, efforts aimed at reducing dementia may need to begin obesity prevention and treatment early in the life course.
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影响因子：
8.3
作者：
Zeki Al Hazzouri A;Vittinghoff E;Sidney S;Reis JP;Jacobs DR Jr;Yaffe K
通讯作者：
Yaffe K
影响因子：
9.9
作者：
Barnes, LL;Wilson, RS;Bennett, DA
通讯作者：
Bennett, DA
DOI：
10.1210/jc.2010-0730
发表时间：
2010-12
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Fransson EI;Batty GD;Tabák AG;Brunner EJ;Kumari M;Shipley MJ;Singh-Manoux A;Kivimäki M
通讯作者：
Kivimäki M
影响因子：
--
作者：
Johnson, David K.;Wilkins, Consuelo H.;Morris, John C.
通讯作者：
Morris, John C.
影响因子：
9.3
作者：
Karlsson, Ida K.;Lehto, Kelli;Dahl Aslan, Anna K.
通讯作者：
Dahl Aslan, Anna K.