Association between change in body composition and change in inflammatory markers: an 11-year follow-up in the Whitehall II Study.
Association between change in body composition and change in inflammatory markers: an 11-year follow-up in the Whitehall II Study.
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DOI：
10.1210/jc.2010-0730
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Kivimäki M
中科院分区：
文献类型：
--
作者：
Fransson EI;Batty GD;Tabák AG;Brunner EJ;Kumari M;Shipley MJ;Singh-Manoux A;Kivimäki M
肥胖与低度炎症有关，但体重变化对炎症的长期影响尚不清楚。检查体重、体重指数（BMI）和腰围变化与C反应蛋白（CRP）和白细胞介素-6（IL-6）变化的相关性，并评估这种相关性是否因基线肥胖状态而改变。公务员前瞻性队列研究（英国白厅II研究）。我们使用了1991-1993年和2002-2004年进行的两次临床筛查的数据（平均随访11.3年）。2496名男性和1026名女性（基线时平均年龄49.4 [SD=6.0]岁），在基线和随访时进行炎症标志物和人体测量。随访期间血清CRP和IL-6的变化。随访期间，体重每增加1 kg，CRP和IL-6的平均增加分别为0.08（95% CI：0.07-0.09）mg/L和0.04（95% CI：0.03-0.05）pg/L。基线时BMI<25 kg/m2的研究成员CRP平均增加0.06（95%CI：0.05-0.08）mg/L/kg体重增加，而超重者增加（25≤BMI<30 kg/m2）和肥胖（BMI≥30 kg/m2）的风险更高：分别为0.08（95% CI：0.06-0.09）mg/L和0.11（95% CI：0.07-0.14）mg/L（相互作用的P值=0.002）。BMI和腰围的变化也观察到类似的模式。基线时超重或肥胖的人，体重、BMI和腰围每增加一个单位，CRP的绝对增加比正常体重的人要大。
Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown. To examine the association of change in weight, body mass index (BMI) and waist circumference with change in C-reactive protein (CRP) and interleukin-6 (IL-6), and to assess whether this association is modified by baseline obesity status. A prospective cohort study among civil servants (the Whitehall II study, UK). We used data from two clinical screenings carried out in 1991–1993 and 2002–2004 (mean follow-up 11.3 years). 2496 men and 1026 women (mean age 49.4 [SD=6.0] years at baseline) with measurements on inflammatory markers and anthropometry at both baseline and follow-up. Change in serum CRP and IL-6 during follow-up. The mean increases in CRP and IL-6 were 0.08 (95% CI: 0.07–0.09) mg/L and 0.04 (95% CI: 0.03–0.05) pg/L per 1-kg increase in body weight during follow-up. Study members with a BMI<25 kg/m2 at baseline had an average increase in CRP of 0.06 (95% CI: 0.05–0.08) mg/L per 1-kg increase in body weight, while the increase in those who were overweight (25≤BMI<30 kg/m2) and obese (BMI≥30 kg/m2) was greater: 0.08 (95% CI 0.06–0.09) mg/L and 0.11 (95% CI: 0.07–0.14) mg/L, respectively (P-value for interaction=0.002). Similar patterns were observed for changes in BMI and waist circumference. Those who were overweight or obese at baseline had a greater absolute increase in CRP per unit increase in weight, BMI and waist circumference, than people who were normal weight.
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DOI：
10.1258/mi.2008.008018
发表时间：
2008-12-01
期刊：
Menopause international
影响因子：
--
作者：
Magliano, Malgorzata
通讯作者：
Magliano, Malgorzata
影响因子：
15.9
作者：
Pepys, MB;Hirschfield, GM
通讯作者：
Hirschfield, GM
影响因子：
120.7
作者：
Visser, M;Bouter, LM;Harris, TB
通讯作者：
Harris, TB
影响因子：
168.9
作者：
MARMOT, MG;SMITH, GD;FEENEY, A
通讯作者：
FEENEY, A
影响因子：
7.1
作者：
Martin, ASG;Obin, MS
通讯作者：
Obin, MS