Deviant functional magnetic resonance imaging patterns of brain activity to speech in 2-3-year-old children with autism spectrum disorder.
Deviant functional magnetic resonance imaging patterns of brain activity to speech in 2-3-year-old children with autism spectrum disorder.
复制标题
DOI：
10.1016/j.biopsych.2008.05.020
复制
发表时间：
2008-10-01
影响因子：
10.6
通讯作者：
Courchesne, Eric
中科院分区：
文献类型：
--
作者：
Redcay, Elizabeth;Courchesne, Eric
无法发展正常语言是幼儿可能面临自闭症风险的最常见的最初迹象之一。目前，语言发展失败背后的神经基础尚不清楚。在这项研究中，利用功能磁共振成像 (fMRI) 来识别 12 名 2-3 岁患有自闭症谱系障碍 (ASD) 儿童在自然睡眠期间参与言语感知的大脑区域。我们还记录了两个典型发育对照组的功能磁共振成像数据：心理年龄匹配（MA）（n = 11）组和时间年龄匹配（CA）（n = 12）组。在功能磁共振成像数据采集过程中，向前和向后的语音刺激被呈现，中间没有声音呈现。各组之间的直接统计比较揭示了用于处理言语的区域的显着差异。与 MA 匹配的对照组相比，自闭症谱系障碍组的大脑区域扩展网络的活动减少，这些区域是在典型的早期语言习得过程中招募的。与 CA 匹配的对照组相比，自闭症谱系障碍参与者主要在右侧和内侧额叶区域表现出更大的激活。偏侧性分析显示，在前向言语条件下，ASD 组的右半球区域和 CA 组的左半球区域有更多募集的趋势。此外，相关性分析显示，右半球额叶和颞叶活动与转发言语和接受性语言技能之间存在显着的正相关关系。这些发现表明，在 2-3 岁时，患有自闭症谱系障碍的儿童可能处于异常的发展轨迹，其特点是在言语感知过程中右半球区域的募集更多。
A failure to develop normal language is one of the most common first signs that a toddler might be at risk for autism. Currently the neural bases underlying this failure to develop language are unknown. In this study, functional magnetic resonance imaging (fMRI) was utilized to identify the brain regions involved in speech perception in 12 2–3 year-old children with autism spectrum disorder (ASD) during natural sleep. We also recorded fMRI data from two typically developing control groups: a mental age-matched (MA) (n=11) and a chronological age-matched (CA) (n=12) group. During fMRI data acquisition, forward and backward speech stimuli were presented with intervening periods of no sound presentation. Direct statistical comparison between groups revealed significant differences in regions recruited to process speech. In comparison to their MA-matched controls, the ASD group showed reduced activity in an extended network of brain regions, which are recruited in typical early language acquisition. In comparison to their CA-matched controls, ASD participants showed greater activation primarily within right and medial frontal regions. Laterality analyses revealed a trend towards greater recruitment of right hemisphere regions in the ASD group and left hemisphere regions in the CA group during the forward speech condition. Furthermore, correlation analyses revealed a significant positive relationship between right hemisphere frontal and temporal activity to forward speech and receptive language skill. These findings suggest that at 2–3 years, children with ASD may be on a deviant developmental trajectory characterized by a greater recruitment of right hemisphere regions during speech perception.
登录
查看更多内容
影响因子：
11.2
作者：
CHI, JG;DOOLING, EC;GILLES, FH
通讯作者：
GILLES, FH
影响因子：
4.6
作者：
DAWSON, G;FINLEY, C;GALPERT, L
通讯作者：
GALPERT, L
影响因子：
5.7
作者：
Carper, RA;Moses, P;Courchesne, E
通讯作者：
Courchesne, E
影响因子：
9.9
作者：
Aylward, EH;Minshew, NJ;Singh, N
通讯作者：
Singh, N
DOI：
10.1073/pnas.0606302103
发表时间：
2006-09-19
影响因子：
11.1
作者：
Dehaene-Lambertz, Ghislaine;Hertz-Pannier, Lucie;Dehaene, Stanislas
通讯作者：
Dehaene, Stanislas