Immunotherapy in the context of immune-specialized environment of brain metastases
Immunotherapy in the context of immune-specialized environment of brain metastases
复制标题
脑转移瘤免疫特异性环境下的免疫治疗
DOI：
10.1093/discim/kyad023
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
James F
中科院分区：
文献类型：
--
作者：
James F
20-40% 的晚期癌症患者会出现脑转移 (BrM)。它们主要起源于肺癌、黑色素瘤、乳腺癌和肾细胞癌，且预后不良。虽然 BrM 患者传统上缺乏有效的治疗选择，但免疫疗法在这组患者中越来越重要，过去十年的临床试验证明了免疫检查点阻断对源自特定肿瘤类型（最重要的是黑色素瘤）的 BrM 的有效性和安全性。大脑是一个免疫专门环境，具有多种独特的分子、细胞和解剖学特征，这些特征会影响免疫反应，包括针对肿瘤的免疫反应。在这篇综述中，我们讨论了其中一些独特特征可能在免疫治疗疗效中发挥的潜在作用，主要关注大脑中的淋巴引流以及由于除 BrM 之外同时存在颅外疾病而产生的全身抗肿瘤免疫的作用。
Brain metastases (BrM) develop in 20–40% of patients with advanced cancer. They mainly originate from lung cancer, melanoma, breast cancer, and renal cell carcinoma, and are associated with a poor prognosis. While patients with BrM traditionally lack effective treatment options, immunotherapy is increasingly gaining in importance in this group of patients, with clinical trials in the past decade demonstrating the efficacy and safety of immune checkpoint blockade in BrM originating from specific tumor types, foremost melanoma. The brain is an immune-specialized environment with several unique molecular, cellular, and anatomical features that affect immune responses, including those against tumors. In this review we discuss the potential role that some of these unique characteristics may play in the efficacy of immunotherapy, mainly focusing on the lymphatic drainage in the brain and the role of systemic anti-tumor immunity that develops due to the presence of concurrent extracranial disease in addition to BrM.
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DOI：
10.1016/s1470-2045(16)30053-5
发表时间：
2016-07
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Goldberg SB;Gettinger SN;Mahajan A;Chiang AC;Herbst RS;Sznol M;Tsiouris AJ;Cohen J;Vortmeyer A;Jilaveanu L;Yu J;Hegde U;Speaker S;Madura M;Ralabate A;Rivera A;Rowen E;Gerrish H;Yao X;Chiang V;Kluger HM
通讯作者：
Kluger HM
影响因子：
32.4
作者：
Prokhnevska, Nataliya;Cardenas, Maria A.;Valanparambil, Rajesh M.;Sobierajska, Ewelina;Barwick, Benjamin G.;Jansen, Caroline;Moon, Adriana Reyes;Gregorova, Petra;delBalzo, Luke;Greenwald, Rachel;Bilen, Mehmet Asim;Alemozaffar, Mehrdad;Joshi, Shreyas;Cimmino, Cara;Larsen, Christian;Master, Viraj;Sanda, Martin;Kissick, Haydn
通讯作者：
Kissick, Haydn
影响因子：
4.7
作者：
通讯作者：
--
将干扰素-α转染的树突状细胞递送至中枢神经系统肿瘤中可增强外周肽疫苗的抗肿瘤功效
影响因子：
11.2
作者：
H. Okada;T. Tsugawa;Hidemitsu Sato;N. Kuwashima;A. Gambotto;K. Okada;Jill E. Dusak;W. Fellows;G. Papworth;Simon C Watkins;W. Chambers;D. Potter;W. Storkus;I. Pollack
通讯作者：
I. Pollack
影响因子：
51.1
作者：
Margolin, Kim;Ernstoff, Marc S.;Hodi, F. Stephen
通讯作者：
Hodi, F. Stephen