Protective Effects and Network Analysis of Ginsenoside Rb1 Against Cerebral Ischemia Injury: A Pharmacological Review.
Protective Effects and Network Analysis of Ginsenoside Rb1 Against Cerebral Ischemia Injury: A Pharmacological Review.
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人参皂苷 Rb1 对脑缺血损伤的保护作用及网络分析：药理学综述
DOI：
10.3389/fphar.2021.604811
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发表时间：
2021
影响因子：
5.6
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Xie W;Wang X;Xiao T;Cao Y;Wu Y;Yang D;Zhang S
缺血性中风是世界范围内死亡和残疾的主要原因。目前，只有有限数量的药物可用于治疗缺血性中风。因此，迫切需要探索和开发其他潜在的预防和治疗缺血性卒中的策略和药物。人参Rb1 （GRb1）是一种从中药中提取的天然有效成分，对中枢神经系统具有神经保护作用。我们就GRb1对缺血性脑损伤的保护作用及机制进行探讨和总结，为开发治疗缺血性脑卒中的新药提供有价值的参考和见解。我们总结的结果表明，GRb1在体内和体外都对脑缺血损伤具有显著的神经保护作用，这些网络作用和潜在的机制是通过抗氧化、抗炎和抗凋亡活性介导的，涉及抑制兴奋毒性和Ca2+内流、保持血脑屏障（BBB）完整性和维持能量代谢。这些发现表明GRb1有潜力作为治疗缺血性卒中的候选药物。进一步的研究，特别是临床试验，将是重要的，以确认其在临床环境中的治疗价值。
Ischemic stroke is a leading cause of death and disability worldwide. Currently, only a limited number of drugs are available for treating ischemic stroke. Hence, studies aiming to explore and develop other potential strategies and agents for preventing and treating ischemic stroke are urgently needed. Ginseng Rb1 (GRb1), a saponin from natural active ingredients derived from traditional Chinese medicine (TCM), exerts neuroprotective effects on the central nervous system (CNS). We conducted this review to explore and summarize the protective effects and mechanisms of GRb1 on cerebral ischemic injury, providing a valuable reference and insights for developing new agents to treat ischemic stroke. Our summarized results indicate that GRb1 exerts significant neuroprotective effects on cerebral ischemic injury both in vivo and in vitro, and these network actions and underlying mechanisms are mediated by antioxidant, anti-inflammatory, and antiapoptotic activities and involve the inhibition of excitotoxicity and Ca2+ influx, preservation of blood–brain barrier (BBB) integrity, and maintenance of energy metabolism. These findings indicate the potential of GRb1 as a candidate drug for treating ischemic stroke. Further studies, in particular clinical trials, will be important to confirm its therapeutic value in a clinical setting.
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