Bacterial toxins: Offensive, defensive, or something else altogether?

Bacterial toxins: Offensive, defensive, or something else altogether?
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DOI:
10.1371/journal.ppat.1006452
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发表时间:
2017-09
期刊:
影响因子:
6.7
通讯作者:
Massey RC
Massey RC
中科院分区:
医学1区
文献类型:
--
作者:
Rudkin JK;McLoughlin RM;Preston A;Massey RC

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破坏宿主组织的蛋白质的分泌被公认为是许多细菌病原体的感染过程的组成部分。然而,我们对毒素活性的理解的最新进展表明,我们从早期体外实验中赋予它们的属性误导了我们,使我们认为它们仅仅是破坏性的工具。在这里,我们将讨论毒素对细菌生活方式的各种影响,并从进化的角度考虑它们的活动,证明这远远超出了它们破坏宿主组织的能力。
The secretion of proteins that damage host tissue is well established as integral to the infectious processes of many bacterial pathogens. However, recent advances in our understanding of the activity of toxins suggest that the attributes we have assigned to them from early in vitro experimentation have misled us into thinking of them as merely destructive tools. Here, we will discuss the multifarious ways in which toxins contribute to the lifestyle of bacteria and, by considering their activity from an evolutionary perspective, demonstrate how this extends far beyond their ability to destroy host tissue.
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