Antibacterial particles and predatory bacteria as alternatives to antibacterial chemicals in the era of antibiotic resistance.
Antibacterial particles and predatory bacteria as alternatives to antibacterial chemicals in the era of antibiotic resistance.
复制标题
DOI：
10.1016/j.mib.2021.09.016
复制
发表时间：
2021-12
影响因子：
5.4
通讯作者：
Novick RP
中科院分区：
文献类型：
--
作者：
Novick RP
这篇评论的重点是亚组的抗菌剂，其行动涉及一对一的目标感染细菌。这些药剂靶向单个细菌，其功效基于颗粒数量，而抗生素等化学药剂的功效基于最小抑制浓度。此类现存的四个成员是掠夺性细菌、功能性（噬菌斑形成）噬菌体和工程颗粒系统、噬菌粒（包含噬菌体包装信号的质粒）和包装携带抗菌基因的染色体岛DNA的抗菌雄蜂（ABD）。我们区分自然的捕食者，寄生虫和捕食性细菌，从工程交付车辆，噬菌粒和ABD，因为后者是更加多才多艺，可以在很大程度上绕过历史战争，通知捕食者-猎物的相互作用。
This review is focused on the subset of antibacterial agents whose action involves one-on-one targeting of infecting bacteria. These agents target individual bacteria and their efficacy is based on particle numbers in contrast to chemical agents such as antibiotics, whose efficacy is based on minimal inhibitory concentrations. Four extant members of this class are predatory bacteria, functional (plaque-forming) phages, and engineered particulate systems, phagemids (plasmids that contain a phage packaging signal) and antibacterial drones (ABDs) that package chromosomal island DNA carrying antibacterial genes. We differentiate the natural predators, phages and predatory bacteria, from the engineered delivery vehicles, phagemids and ABDs, because the latter are much more versatile and can largely bypass the historical warfare that informs the predator-prey interactions.
登录
查看更多内容
影响因子：
46.9
作者：
Bikard, David;Euler, Chad W.;Jiang, Wenyan;Nussenzweig, Philip M.;Goldberg, Gregory W.;Duportet, Xavier;Fischetti, Vincent A.;Marraffini, Luciano A.
通讯作者：
Marraffini, Luciano A.
影响因子：
4.6
作者：
Botka, Tibor;Pantucek, Roman;Doskar, Jiri
通讯作者：
Doskar, Jiri
影响因子：
4.4
作者：
Kadouri, D;O'Toole, GA
通讯作者：
O'Toole, GA
影响因子：
5.2
作者：
Iebba, Valerio;Totino, Valentina;Schippa, Serena
通讯作者：
Schippa, Serena
影响因子：
9.3
作者：
Ando, Hiroki;Lemire, Sebastien;Lu, Timothy K.
通讯作者：
Lu, Timothy K.