The complement cascade as a mediator of tissue growth and regeneration.
The complement cascade as a mediator of tissue growth and regeneration.
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DOI：
10.1007/s00011-010-0220-6
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发表时间：
2010-11
影响因子：
6.7
通讯作者：
Parsa, Andrew T.
中科院分区：
文献类型：
--
作者：
Rutkowski, Martin J.;Sughrue, Michael E.;Kane, Ari J.;Ahn, Brian J.;Fang, Shanna;Parsa, Andrew T.
最近的证据表明，补体级联除了作为免疫效应器的作用外，还参与了多种生理和病理生理过程。对多种器官系统的研究表明，补体蛋白是维持细胞周转、愈合、增殖和再生的直接参与者。作为一种生理管家，补体蛋白通过处理细胞碎片和废物在没有炎症的情况下保持组织完整性，这是预防自身免疫性疾病的关键过程。在发育过程中，补体蛋白会影响包括造血干细胞植入、骨生长和血管生成在内的多种途径。它们还为细胞增殖提供了强有力的刺激，包括动物模型中肢体和眼睛的再生，以及损伤后的肝脏增殖。在这里，我们将补体级联描述为组织生长和再生的中介。
Recent evidence has demonstrated that the complement cascade is involved in a variety of physiologic and pathophysiologic processes in addition to its role as an immune effector. Research in a variety of organ systems has shown that complement proteins are direct participants in maintenance of cellular turnover, healing, proliferation and regeneration. As a physiologic housekeeper, complement proteins maintain tissue integrity in the absence of inflammation by disposing of cellular debris and waste, a process critical to the prevention of autoimmune disease. Developmentally, complement proteins influence pathways including hematopoietic stem cell engraftment, bone growth, and angiogenesis. They also provide a potent stimulus for cellular proliferation including regeneration of the limb and eye in animal models, and liver proliferation following injury. Here, we describe the complement cascade as a mediator of tissue growth and regeneration.
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影响因子：
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作者：
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