Drug-Drug Interactions, Effectiveness, and Safety of Hormonal Contraceptives in Women Living with HIV.
Drug-Drug Interactions, Effectiveness, and Safety of Hormonal Contraceptives in Women Living with HIV.
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DOI：
10.1007/s40264-016-0452-7
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发表时间：
2016-11
期刊：
影响因子：
4.2
通讯作者：
Lamorde, Mohammed
中科院分区：
文献类型：
--
作者：
Scarsi, Kimberly K.;Darin, Kristin M.;Chappell, Catherine A.;Nitz, Stephanie M.;Lamorde, Mohammed
包括激素避孕药在内的各种计划生育办法对于改善全世界1 700多万感染人体免疫机能丧失病毒（艾滋病毒）的妇女的生殖健康至关重要。对这些妇女来说，预防意外怀孕可降低孕产妇和儿童死亡率，并减少围产期艾滋病毒传播的风险。同样，用抗逆转录病毒疗法治疗艾滋病毒对于降低艾滋病毒抗体阳性者的发病率和死亡率以及预防性伴侣之间或母婴之间的艾滋病毒传播至关重要。重要的是，尽管激素避孕药有好处，但对艾滋病毒抗体阳性妇女来说，有效的计划生育方法仍然存在障碍。具体而言，药物相互作用可能发生在一些抗逆转录病毒药物和一些激素避孕药之间，这可能会影响避孕效果和耐受性。此外，人们对激素避孕药对艾滋病毒疾病进展、耐受性和女性向男性传播艾滋病毒风险的影响提出了安全性担忧。这篇综述文章总结了潜在的药物相互作用，耐受性和避孕效果时，激素避孕药与ART相结合。此外，周围的证据激素避孕药对艾滋病毒传播和艾滋病毒疾病进展的妇女艾滋病毒感染者的影响进行了总结。
Family planning options, including hormonal contraceptives, are essential for improving reproductive health among the more than 17 million women living with human immunodeficiency virus (HIV) worldwide. For these women, prevention of unintended pregnancy decreases maternal and child mortality, as well as reduces the risk of perinatal HIV transmission. Similarly, treatment of HIV with antiretroviral therapy (ART) is essential for reducing morbidity and mortality among HIV-positive individuals, as well as preventing HIV transmission between sexual partners or from mother to child. Importantly, despite the benefits of hormonal contraceptives, barriers to effective family planning methods exist for HIV-positive women. Specifically, drug-drug interactions can occur between some antiretroviral medications and some hormonal contraceptives, which may influence both contraceptive efficacy and tolerability. In addition, safety concerns have been raised about the impact of hormonal contraceptives on HIV disease progression, tolerability and the risk of female-to-male HIV transmission. This review article summarizes the potential for drug-drug interactions, tolerability, and contraceptive effectiveness when hormonal contraceptives are combined with ART. In addition, the evidence surrounding the influence of hormonal contraceptives on HIV transmission and HIV disease progression in women living with HIV are summarized.
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影响因子：
13.3
作者：
Heikinheimo O;Lähteenmäki P
通讯作者：
Lähteenmäki P
影响因子：
17.1
作者：
Baeten JM;Kahle E;Lingappa JR;Coombs RW;Delany-Moretlwe S;Nakku-Joloba E;Mugo NR;Wald A;Corey L;Donnell D;Campbell MS;Mullins JI;Celum C;Partners in Prevention HSV/HIV Transmission Study Team
通讯作者：
Partners in Prevention HSV/HIV Transmission Study Team
影响因子：
7.2
作者：
通讯作者：
--
影响因子：
--
作者：
Carten ML;Kiser JJ;Kwara A;Mawhinney S;Cu-Uvin S
通讯作者：
Cu-Uvin S
影响因子：
6.7
作者：
Benowitz, Neal L.;Lessov-Schlaggar, Christina N.;Jacob, Peyton, III
通讯作者：
Jacob, Peyton, III