A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus.
A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus.
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DOI：
10.1038/mp.2012.113
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发表时间：
2013-08
影响因子：
11
通讯作者：
Miller, M. W.
中科院分区：
文献类型：
--
作者：
Logue, M. W.;Baldwin, C.;Guffanti, G.;Melista, E.;Wolf, E. J.;Reardon, A. F.;Uddin, M.;Wildman, D.;Galea, S.;Koenen, K. C.;Miller, M. W.
我们描述了创伤后应激障碍的第一个全基因组关联研究的结果，该研究使用创伤暴露的白色非西班牙裔参与者，他们来自一组退伍军人及其亲密伴侣（295例和196例对照）。几个SNP产生了关联的证据。一个SNP（rs 8042149），位于维甲酸相关孤儿受体α基因（RORA），达到全基因组意义。在两个非裔美国人复制样本中观察到其他RORA SNP的名义上显著的关联-一个来自退伍军人队列（43例和41例对照），另一个独立队列（100例和421例对照）。然而，只有来自经验丰富的非洲裔美国人复制样本的相关SNP在基因水平的多重检测校正中幸存下来。RORA已被牵连在先前的GWAS研究的精神疾病，并被称为发挥重要作用，在神经保护和其他行为相关的过程。这项研究代表了确定PTSD遗传基础的重要一步。
We describe the results of the first genome-wide association study of PTSD performed using trauma-exposed white non-Hispanic participants from a cohort of veterans and their intimate partners (295 cases and 196 controls). Several SNPs yielded evidence of association. One SNP (rs8042149), located in the retinoid-related orphan receptor alpha gene (RORA), reached genome-wide significance. Nominally significant associations were observed for other RORA SNPs in two African American replication samples—one from the veteran cohort (43 cases and 41 controls) and another independent cohort (100 cases and 421 controls). However, only the associated SNP from the veteran African American replication sample survived gene-level multiple testing correction. RORA has been implicated in prior GWAS studies of psychiatric disorders and is known to play an important role in neuroprotection and other behaviorally-relevant processes. This study represents an important step towards identifying the genetic underpinnings of PTSD.
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影响因子：
4.3
作者：
Kochunov P;Glahn DC;Nichols TE;Winkler AM;Hong EL;Holcomb HH;Stein JL;Thompson PM;Curran JE;Carless MA;Olvera RL;Johnson MP;Cole SA;Kochunov V;Kent J;Blangero J
通讯作者：
Blangero J
影响因子：
3.3
作者：
Koenen, Karestan C.;Amstadter, Ananda B.;Nugent, Nicole R.
通讯作者：
Nugent, Nicole R.
影响因子：
10.3
作者：
Miller, Mark W.;Wolf, Erika J.;McInerney, Scott
通讯作者：
McInerney, Scott
影响因子：
--
作者：
KESSLER, RC;SONNEGA, A;NELSON, CB
通讯作者：
NELSON, CB
影响因子：
6.7
作者：
Cornelis, Marilyn C.;Nugent, Nicole R.;Amstadter, Ananda B.;Koenen, Karestan C.
通讯作者：
Koenen, Karestan C.