Giant cell arteritis: strategies in diagnosis and treatment
Giant cell arteritis: strategies in diagnosis and treatment
复制标题
巨细胞动脉炎：诊断和治疗策略
DOI：
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发表时间：
2004
影响因子：
5.1
通讯作者：
C. Nordborg
中科院分区：
文献类型：
--
作者：
E. Nordborg;C. Nordborg
综述目的本综述总结了巨细胞动脉炎的当前诊断评估和治疗策略。巨细胞动脉炎或颞动脉炎是大中型血管的慢性血管炎。近端肌肉疼痛和晨僵、风湿性多肌痛的并发症状很常见。最近的研究支持这样的论点：风湿性多肌痛和颞动脉炎是同一潜在血管炎疾病的两种不同表现。最近的发现巨细胞动脉炎的症状差异很大。最近发现音频前庭表现频繁发生，应在临床研究中积极寻找。尽管彩色多普勒超声、MRI 和正电子发射断层扫描已经说明了巨细胞动脉炎的广泛性，但目前这些技术都无法取代颞动脉活检。颞浅动脉活检是一种安全且简单的手术，并且仍然是诊断巨细胞动脉炎的金标准。强调了使用连续切片进行长活检和细致组织学检查的重要性。最近的许多出版物证实了第二次对侧活检的诊断率较低。皮质类固醇仍然是治疗巨细胞动脉炎的基石。尽管类固醇治疗可以迅速消除全身炎症症状，但其对炎症形态的影响却被延迟。因此，需要新的治疗策略。阿司匹林的潜在作用最近受到关注。
Purpose of reviewThis review summarizes current diagnostic assessments and therapeutic strategies in giant cell arteritis. Giant cell arteritis or temporal arteritis is a chronic vasculitis of large and medium-size vessels. Concurrent symptoms of proximal muscular ache and morning stiffness, polymyalgia rheumatica, are commonly seen. Recent investigations support the contention that polymyalgia rheumatica and temporal arteritis are two different expressions of the same underlying vasculitic disorder. Recent findingsThe symptomatology of giant cell arteritis is quite varying. Recently a frequent occurrence of audiovestibular manifestations was demonstrated, which should be actively searched for in the clinical investigation. Although color Doppler ultrasound, MRI, and positron emission tomography have illustrated the widespread nature of giant cell arteritis, none of these techniques may currently replace temporal artery biopsy. Biopsy of the superficial temporal artery is a safe and simple procedure, and remains the gold standard for the diagnosis of giant cell arteritis. The importance of long biopsies and meticulous histologic examination using subserial sectioning is emphasized. Numerous recent publications confirm the low diagnostic yield of a second, contralateral biopsy. Corticosteroids remain the cornerstone in the treatment of giant cell arteritis. Although steroid treatment promptly eliminates symptoms of systemic inflammation, its effect on inflammatory morphology is delayed. Consequently, there is a need for new therapeutic strategies. The potential role of aspirin has recently been implicated.
巨细胞动脉炎的视觉预后。
影响因子：
13.7
作者：
Aiello,PD;Trautmann,JC;McPhee,TJ;Kunselman,AR;Hunder,GG
通讯作者：
Hunder,GG
泼尼松治疗后 6 个月颞动脉活检呈阳性。
DOI：
--
发表时间：
1998
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Guevara,RA;Newman,NJ;Grossniklaus,HE
通讯作者：
Grossniklaus,HE