Automated structure and flow measurement - a promising tool in nailfold capillaroscopy.
Automated structure and flow measurement - a promising tool in nailfold capillaroscopy.
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DOI：
10.1016/j.mvr.2018.03.016
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发表时间：
2018-07
影响因子：
3.1
通讯作者：
Herrick AL
中科院分区：
文献类型：
--
作者：
Berks M;Dinsdale G;Murray A;Moore T;Manning J;Taylor C;Herrick AL
尽管人们对甲襞毛细血管镜检查越来越感兴趣，但对毛细血管结构和血流的客观测量研究很少。我们的目的是验证结构测量、毛细血管流量和联合测量具有预测能力的假设，以区分系统性硬化症（SSc）患者与原发性雷诺氏现象（PRP）和健康对照（HC）患者。50例SSc患者、12例PRP患者和50例HC患者使用一种新型毛细血管镜系统进行成像，该系统可生成高质量的甲襞图像，并提供全自动毛细血管结构和血流测量（毛细血管密度、平均宽度、最大宽度、形状评分、混乱度和平均流速）。人口统计总结了这三个群体之间的差异。ROC曲线下面积（AZ）用来衡量将个体划分为SSc组和HC/PRP组时的分类准确性。SSc、PRP和HC患者的平均宽度（μm） ± SE分别为15.0 ± 0.71、12.7 ± 0.74和11.8 ± 0.23，各组平均差异有统计学意义。结合五个结构测量给更好的分类(AZ = 0.919 ±0.026 )比最好的单一测量(平均宽度,AZ = 0.874 ± 0.043),同时增加流进一步提高分类(AZ = 0.930 ±0.024 )。结构和血流测量都能够区分SSc患者和PRP/HC患者。重要的是，这些有望作为旨在改善手指血流或微血管重塑的治疗的临床试验结果措施。新颖的系统可以快速捕获高质量的毛细管结构和流动图像。甲襞毛细管结构及流量自动测量。结合毛细血管的结构和流动，可以很好地区分疾病和正常。流动，在SSc中显著减少，显示出作为功能结果测量的潜力。
Despite increasing interest in nailfold capillaroscopy, objective measures of capillary structure and blood flow have been little studied. We aimed to test the hypothesis that structural measurements, capillary flow, and a combined measure have the predictive power to separate patients with systemic sclerosis (SSc) from those with primary Raynaud's phenomenon (PRP) and healthy controls (HC). 50 patients with SSc, 12 with PRP, and 50 HC were imaged using a novel capillaroscopy system that generates high-quality nailfold images and provides fully-automated measurements of capillary structure and blood flow (capillary density, mean width, maximum width, shape score, derangement and mean flow velocity). Population statistics summarise the differences between the three groups. Areas under ROC curves (AZ) were used to measure classification accuracy when assigning individuals to SSc and HC/PRP groups. Statistically significant differences in group means were found between patients with SSc and both HC and patients with PRP, for all measurements, e.g. mean width (μm) ± SE: 15.0 ± 0.71, 12.7 ± 0.74 and 11.8 ± 0.23 for SSc, PRP and HC respectively. Combining the five structural measurements gave better classification (AZ = 0.919 ± 0.026) than the best single measurement (mean width, AZ = 0.874 ± 0.043), whilst adding flow further improved classification (AZ = 0.930 ± 0.024). Structural and blood flow measurements are both able to distinguish patients with SSc from those with PRP/HC. Importantly, these hold promise as clinical trial outcome measures for treatments aimed at improving finger blood flow or microvascular remodelling. Novel system allows rapid capture of high-quality capillary structure and flow images. Nailfold capillary structure and flow can be measured automatically. Combining capillary structure and flow strongly discriminates disease from normality. Flow, significantly reduced in SSc, shows potential as a functional outcome measure.
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影响因子：
27.4
作者：
van den Hoogen, Frank;Khanna, Dinesh;Pope, Janet E.
通讯作者：
Pope, Janet E.
影响因子：
5.5
作者：
Mugii, Naoki;Hasegawa, Minoru;Takehara, Kazuhiko
通讯作者：
Takehara, Kazuhiko
影响因子：
--
作者：
MARICQ, HR;LEROY, EC
通讯作者：
LEROY, EC
影响因子：
3.9
作者：
Cutolo, Maurizio;Zampogna, Giuseppe;Sulli, Alberto
通讯作者：
Sulli, Alberto
影响因子：
3.1
作者：
Shih, Tzu-Ching;Zhang, Geoffrey;Huang, Tzung-Chi
通讯作者：
Huang, Tzung-Chi