IRF7: activation, regulation, modification and function.
IRF7: activation, regulation, modification and function.
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DOI：
10.1038/gene.2011.21
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发表时间：
2011-09
影响因子：
5
通讯作者：
Barber, G. N.
中科院分区：
文献类型：
--
作者：
Ning, S.;Pagano, J. S.;Barber, G. N.
干扰素调节因子 7 (IRF7) 最初是在 Epstein-Barr 病毒 (EBV) 感染的背景下被发现的，后来成为 I 型干扰素 (IFN) 对抗病原体感染的关键调节因子，它通过触发识别病原体核酸的病原体识别受体 (PRR) 的信号级联来激活 IRF7。此外，IRF7 是一种多功能转录因子，它与 EBV 潜伏期相关，其中 IRF7 是由 EBV 主要癌蛋白潜伏膜蛋白 1 (LMP1) 诱导和激活的。 I 型干扰素的异常产生与许多类型的疾病有关，例如癌症和自身免疫性疾病。因此，严格调节 IRF7 表达和活性对于确定适当的 I 型 IFN 产生以实现正常 IFN 介导的生理功能至关重要。翻译后修饰在 IRF7 活性的调节中具有重要作用，磷酸化就是例证，磷酸化表明其激活。此外，越来越多的证据揭示了调节泛素化在 IRF7 激活中的重要性。尽管自发现以来的过去十年中已经取得了这些令人兴奋的发现，但与 IRF7 相关的许多问题仍有待解决。
Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I interferons (IFNs) against pathogenic infections, which activate IRF7 by triggering signaling cascades from pathogen recognition receptors (PRRs) that recognize pathogenic nucleic acids. Moreover, IRF7 is a multifunctional transcription factor, underscored by the fact that it is associated with EBV latency, in which IRF7 is induced as well as activated by the EBV principal oncoprotein latent membrane protein-1 (LMP1). Aberrant production of type I IFNs is associated with many types of diseases such as cancers and autoimmune disorders. Thus, tight regulation of IRF7 expression and activity is imperative in dictating appropriate type I IFN production for normal IFN-mediated physiological functions. Posttranslational modifications have important roles in regulation of IRF7 activity, exemplified by phosphorylation, which is indicative of its activation. Furthermore, mounting evidence has shed light on the importance of regulatory ubiquitination in activation of IRF7. Albeit these exciting findings have been made in the past decade since its discovery, many questions related to IRF7 remain to be addressed.
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影响因子：
30.5
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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作者：
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通讯作者：
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