Mechanisms and implications of adaptive immune responses after traumatic spinal cord injury.
Mechanisms and implications of adaptive immune responses after traumatic spinal cord injury.
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DOI：
10.1016/j.neuroscience.2008.07.001
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发表时间：
2009-02-06
期刊：
影响因子：
3.3
通讯作者：
Popovich PG
中科院分区：
文献类型：
--
作者：
Ankeny DP;Popovich PG
哺乳动物的创伤性脊髓损伤 (SCI) 会导致神经胶质细胞广泛激活，并招募先天性（例如中性粒细胞、单核细胞）和适应性（例如 T 和 B 淋巴细胞）免疫细胞到 CNS。迄今为止，大多数研究都试图了解或操纵星形胶质细胞、小胶质细胞、中性粒细胞或单核细胞的创伤后功能。对于 SCI 诱导的淋巴细胞激活的后果知之甚少。然而，新出现的数据表明，T 细胞和 B 细胞被 SCI 激活，并在形成创伤后炎症以及神经退行性和修复的下游级联反应中发挥重要作用。在这里，我们为神经生物学家提供了对 SCI 诱导淋巴细胞激活的机制和影响的及时回顾，包括对旨在操纵淋巴细胞功能以获得治疗效果的不同实验策略的讨论。
Traumatic spinal cord injury (SCI) in mammals causes widespread glial activation and recruitment to the CNS of innate (e.g., neutrophils, monocytes) and adaptive (e.g., T and B lymphocytes) immune cells. To date, most studies have sought to understand or manipulate the post-traumatic functions of astrocytes, microglia, neutrophils or monocytes. Significantly less is known about the consequences of SCI-induced lymphocyte activation. Yet, emerging data suggest that T and B cells are activated by SCI and play significant roles in shaping post-traumatic inflammation and downstream cascades of neurodegeneration and repair. Here, we provide neurobiologists with a timely review of the mechanisms and implications of SCI-induced lymphocyte activation, including a discussion of different experimental strategies that have been designed to manipulate lymphocyte function for therapeutic gain.
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