Expanded roles for the MutL family of DNA mismatch repair proteins.
Expanded roles for the MutL family of DNA mismatch repair proteins.
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DOI：
10.1002/yea.3512
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Alani E
中科院分区：
文献类型：
--
作者：
Furman CM;Elbashir R;Alani E
MutL家族的DNA错配修复蛋白在切除和修复DNA复制过程中的错配错误中起着关键作用。在许多真核生物中，这个家族的成员已经进化到在减数分裂过程中调节和分解重组中间产物为交叉。在这些生物体中，这些功能促进了减数分裂I期染色体的准确分离。MutL Homolog(MLH)家族成员发生了哪些变化，使他们能够获得这些新角色？在这篇综述中，我们提出证据表明，酵母MLH1-Mlh3和MLH1-Mlh2复合体已经进化出新的酶和非酶活性以及蛋白质-蛋白质相互作用，这对它们的减数分裂功能至关重要。奇怪的是，即使有了这些变化，这些复合体仍在营养生长过程中保留了DNA错配修复的备份和辅助角色。
The MutL family of DNA mismatch repair proteins plays a critical role in excising and repairing misincorporation errors during DNA replication. In many eukaryotes, members of this family have evolved to modulate and resolve recombination intermediates into crossovers during meiosis. In these organisms, such functions promote the accurate segregation of chromosomes during the Meiosis I division. What alterations occurred in MutL homolog (MLH) family members that enabled them to acquire these new roles? In this review we present evidence that the yeast Mlh1-Mlh3 and Mlh1-Mlh2 complexes have evolved novel enzymatic and nonenzymatic activities and protein-protein interactions that are critical for their meiotic functions. Curiously, even with these changes, these complexes retain backup and accessory roles in DNA mismatch repair during vegetative growth.
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影响因子：
3.3
作者：
Clark, Nathan L.;Alani, Eric;Aquadro, Charles F.
通讯作者：
Aquadro, Charles F.
DOI：
10.1126/science.1219379
发表时间：
2012-09-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cloud V;Chan YL;Grubb J;Budke B;Bishop DK
通讯作者：
Bishop DK
影响因子：
4.5
作者：
Al-Sweel N;Raghavan V;Dutta A;Ajith VP;Di Vietro L;Khondakar N;Manhart CM;Surtees JA;Nishant KT;Alani E
通讯作者：
Alani E
影响因子：
14.9
作者：
Chan, Yuen-Ling;Zhang, Annie;Bishop, Douglas K.
通讯作者：
Bishop, Douglas K.
影响因子：
4.5
作者：
Brown MS;Grubb J;Zhang A;Rust MJ;Bishop DK
通讯作者：
Bishop DK