T Follicular Helper-Like Cells in Inflamed Non-Lymphoid Tissues.
T Follicular Helper-Like Cells in Inflamed Non-Lymphoid Tissues.
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DOI：
10.3389/fimmu.2018.01707
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发表时间：
2018
影响因子：
7.3
通讯作者：
Hutloff A
中科院分区：
文献类型：
--
作者：
Hutloff A
T和B细胞的合作通常发生在次级淋巴器官（SLO）。然而，这两种细胞类型也经常在发炎的非淋巴组织中发现。在某些条件下，这些浸润发展成异位淋巴样结构，也称为三级淋巴样组织，其结构和功能完全类似于SLO中的生发中心（GC）。然而，在大多数人类自身免疫性疾病中，三级淋巴组织并不常见;相反，发现了相对非结构化的T和B细胞浸润。最近的研究表明，活跃的T和B细胞合作也可以发生在这种非结构化的聚集体中。浸润细胞含有T滤泡辅助（Tfh）样细胞（也称为“外周T辅助细胞”）群，其缺乏原型Tfh标志物如CXCR 5和Bcl-6，但仍表达高水平的对B细胞辅助重要的分子如IL-21和CD 40 L。此外，从发炎组织中分离的Tfh样细胞可以在体外驱动B细胞分化为抗体分泌细胞。这些发现并不局限于实验动物模型，而是在类风湿性关节炎和乳腺癌患者中重现。在这一点上，还不清楚T和B细胞在GC有序结构之外的合作是否完全反映了SLO中的反应。然而，炎症组织中的Tfh样细胞对于B细胞局部分化为抗体分泌细胞当然很重要，应被视为治疗自身免疫性疾病的重要靶点。
T and B cell cooperation normally takes place in secondary lymphoid organs (SLO). However, both cell types are also frequently found in inflamed non-lymphoid tissues. Under certain conditions, these infiltrates develop into ectopic lymphoid structures, also known as tertiary lymphoid tissues, which structurally and functionally fully resemble germinal centers (GCs) in SLO. However, tertiary lymphoid tissue is uncommon in most human autoimmune conditions; instead, relatively unstructured T and B cell infiltrates are found. Recent studies have demonstrated that active T and B cell cooperation can also take place in such unstructured aggregates. The infiltrating cells contain a population of T follicular helper (Tfh)-like cells (also designated “peripheral T helper cells”) lacking prototypic Tfh markers like CXCR5 and Bcl-6 but nevertheless expressing high levels of molecules important for B cell help like IL-21 and CD40L. Moreover, Tfh-like cells isolated from inflamed tissues can drive the differentiation of B cells into antibody-secreting cells in vitro. These findings are not restricted to experimental animal models but have been reproduced in rheumatoid arthritis and breast cancer patients. At this point, it is unclear whether T and B cell cooperation outside the ordered structure of the GC fully mirrors the reactions in SLO. However, Tfh-like cells in inflamed tissues are certainly important for the local differentiation of B cells into antibody-secreting cells, and should be considered as an important target for the treatment of autoimmune diseases.
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影响因子：
4.6
作者：
Maehara T;Moriyama M;Hayashida JN;Tanaka A;Shinozaki S;Kubo Y;Matsumura K;Nakamura S
通讯作者：
Nakamura S
影响因子：
--
作者：
Hutloff, A;B端chner, K;Kroczek, RA
通讯作者：
Kroczek, RA
影响因子：
15.9
作者：
Gu-Trantien, Chunyan;Loi, Sherene;Willard-Gallo, Karen
通讯作者：
Willard-Gallo, Karen
影响因子：
16.6
作者：
Vu Van D;Beier KC;Pietzke LJ;Al Baz MS;Feist RK;Gurka S;Hamelmann E;Kroczek RA;Hutloff A
通讯作者：
Hutloff A
影响因子：
32.4
作者：
Mesin, Luka;Ersching, Jonatan;Victora, Gabriel D.
通讯作者：
Victora, Gabriel D.